Caprisa - Scientific Publication

Urgent need for a reliable rapid diagnostic test for the Ebola epidemic caused by Bundibugyo virus in Africa

Safura Abdool Karim, Sharana Mahomed, Lara Lewis, Salim S Abdool Karim

The Lancet

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Optimizing personalized screening intervals for clinical biomarkers using extended joint models

Mchunu NN, Mwambi H, Reddy T, Yende-Zuma N, Rizopoulos D

Journal of Applied Statistics

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Pharmacokinetics of Twice-daily Tenofovir Alafenamide in Adults With HIV-associated Tuberculosis on Bictegravir/Emtricitabine/Tenofovir Alafenamide and Rifampicin

Osuala EC, Nkuhairwe IN, Letsoalo MP, Naidoo K, Perumal R, Rooney JF, Wiesner L, Wasmann RE, Denti P, Dooley KE, Naidoo A; INSIGHT Study Team

Clinical Infectious Diseases

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Pre-Human Immunodeficiency Virus (HIV) infection Th17 CD4+ T cells as predictors of early HIV disease progression

Omole TE, Nguyen HM, Marcinow A et al

PLoS Pathogens

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Contemporary HIV-1 envelope pseudovirus panels for detecting and assessing B cell lineages with broadly neutralizing antibody potential

Korber B, Seaman MS, Mkhize NN et al

PLoS Pathogens

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Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients

Butler CC, Pinto AD, Harris V, Holmes J et al

NEJM

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Impact of tenofovir alafenamide sub-dermal implant insertion site scarring on acceptability and HIV prevention preferences: a prospective cohort study in Durban, South Africa

Gengiah TN, Lewis L, Harkoo I, Myeni N, Mansoor LE, Abdool Karim SS, Abdool Karim Q

Journal of the International AIDS Society

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Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV

Kowarsky M, Dalman M, Moufarrej MN et al

PLoS Pathogens

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VIBRANT: A phase 1 randomized trial of multi-strain vaginal L. crispatus live biotherapeutic products in people with bacterial vaginosis

Potloane D, Symul L, Ngcapu S, Lewis L et al

Cell Host Microbe

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Ethical design as a prerequisite for translational microbiome science

Passmore JS, Nieves Delgado A, et al

Microbiome

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Defining the mechanism of cross-reactivity for a SARS-CoV-2 Beta-elicited antibody toward omicron sub-lineages

Ayres F, Lambson B, Mkhize NN et al

Structure

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Lessons learned from viral hepatitis testing that inform law and policy responses to steatotic liver disease

Lazarus JV, Kopka CJ, Nicolàs A, Karim SA et al

Nature Reviews Gastroenterology & Hepatology

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Inflammatory Biomarkers Predicting Major Adverse Cardiovascular Events in People Living With HIV: A Systematic Review and Meta-Analysis

Murray A, Louwman N, Luk A et al

Journal of the International AIDS Society

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Adherence to Oral HIV Pre-exposure Prophylaxis During Pregnancy and the Post-partum Period: Lessons Learned in an Open-Labelled Clinical Trial

Khoza N, Desmond AC, Moodley D

AIDS and Behavior

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Treatment outcomes and drug-related adverse events across four short-course RR-TB regimens in South Africa: A retrospective analysis

Ndjeka N, Perumal R, Romanowski K et al

International Journal of Infectious Diseases

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HLA Class II Protein Expression Regulation Is Strongly Linked to Cis-Acting SNPs. HLA

Vince N, Ramsuran V, Viard M et al

HLA

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Lenacapavir as pre-exposure prophylaxis for HIV prevention

Ebrahim S, Gloeck N, Adam Z et al

Cochrane Database of Systematic Reviews

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Navigating "Wicked" Disagreement in Public Health

Karim SA, Faden R, Barnhill A et al

American Journal of Public Health

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Catalysing future research on the under-recognised burden of post-tuberculosis pulmonary hypertension

Perumal R

African Journal of Thoracic and Critical Care Medicine

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Body mass index (BMI) at RR-TB diagnosis as an independent predictor of treatment outcomes: a retrospective analysis

Mzinyane N, Perumal R, Amusa LB, Chetty D, Shunmugam L, Boodhram R, Narasimmulu R, O'Donnell M, Wolf A, Padayatchi N, Naidoo K

BMC Infectious Diseases

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Quality assessment of data for decentralised antiretroviral therapy referrals and laboratory results in the South African national electronic HIV management register TIER.Net

Naidu L, van der Molen J, Jugathpal V et al

PLOS Global Public Health

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Preventing tuberculosis in advanced HIV disease

Perumal R, Naidoo K

Lancet HIV

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The vaginal microbiome in pregnancy and preterm birth: mechanisms, disparities, and therapeutic opportunities

Pillay N, Short CS, Mzobe GF, Mtshali A, Ngcapu S

NPJ Biofilms Microbiomes

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Quality of life among people with tuberculosis in the Eastern Cape, South Africa: a qualitative study

Bedingfield N, Fiphaza K, Girma M et al

BMC Global and Public Health

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Method Comparison of Dried Blood Spot and Plasma Apolipoprotein B Measurement on a Semi-Automated Analyser: Toward Accessible Lipid Profiling in Resource-Limited Settings

Pitampersad B, Madurai S, Manivannan B, Pillay K, Mahomed S

Analytical Science Advances

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Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

Han N, Loosli T, Sauermann M et al

Journal of Antimicrobial Chemotherapy

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Point-of-care HIV viral load testing in a community antiretroviral therapy delivery programme: A randomised controlled trial (PHILA)

Dorward J, Tlhaku K, Sookrajh Y et al

PLOS Global Public Health

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Enumeration, Phenotyping, and Clinical Associations of Tissue-Resident T Cells in the Ecto- and Endocervix of Women Attending a Colposcopy Clinic

Ssemaganda A, Kahia N, Oo MM et al

American Journal of Reproductive Immunology

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Association of human papillomavirus on risk of HIV acquisition in African women: analyses from MTN-020/ASPIRE

Hathaway CL, Brown ER, Cherne S

Journal of the National Cancer Institute

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Safety and immunogenicity of a single dose of Ad26.COV2.S, BNT162b2, or SARS-CoV-2-rS-protein-nanoparticle in previously vaccinated and unvaccinated adults living with and without HIV in South Africa: a phase 2a randomised, observer-blind trial

Govender V, Reddy T, Maenetje P, Beattie T et al

Lancet HIV

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HLA typing of HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 loci of 226 individuals from three metropolitan areas in South Africa

Suzuki A, Baguma R, Sawry S et al

Human Immunology

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Enumeration, Phenotyping, and Clinical Associations of Tissue-Resident T Cells in the Ecto- and Endocervix of Women Attending a Colposcopy Clinic

Ssemaganda A, Kahia N, Oo MM

American Journal of Reproductive Immunology

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Approaches to the Management of Virologic Failure on Dolutegravir-Based Antiretroviral Therapy in the 50 Countries With the Highest Adult HIV Prevalence

Nutt CT, Lessells RJ, Muyindike WR et al

Clinical Infectious Diseases

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The cost-effectiveness of male-partner treatment to prevent recurrence of bacterial vaginosis

Zhang Y, Bradshaw CS, Masson L et al

Scientific Reports (Nature)

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Recruiting people who inject drugs (PWID) into research: benefits and challenges of respondent driven sampling (RDS) in a sample in KwaZulu-Natal, South Africa

Milford C, Hardwick TS, Bosman S et al

Substance Abuse Treatment, Prevention, and Policy

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Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women

Bunjun R, Lurie M, Dabee S et al

Journal of Infectious Diseases

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Place susceptibility index mapping at local government scale from population-based survey for Sub-Saharan Africa

Lawal O, Okon M, Blanco N et al

PLoS One

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Developing and testing unconditional cash transfer strategies among young adults with first-episode psychosis in South Africa: a study protocol for a pilot randomised control trial (PRS-FEP trial)

Mlay JP, Jamieson L, Ntlantsana V et al

BMJ Open

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Unmet needs of young adults following first-episode psychosis in KwaZulu-Natal, South Africa: Baseline findings from a pilot randomised controlled trial of basic income support

Mlay JP, Ntlantsana V, Gcabashe N et al

South African Journal of Psychiatry

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Pharmacokinetic modelling as a tool to assess TB treatment adherence: application to the REMEMBER study

Abdelgawad N, Chirehwa M, McIlleron H et al

The International Journal of Tuberculosis and Lung Disease (IJTLD) Open

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Safety, antiviral activity, and pharmacokinetics of long-acting injectable cabotegravir-rilpivirine in virologically suppressed adolescents living with HIV-1 (IMPAACT 2017/MOCHA): 48-week results of a multinational, phase 1/2, single-arm study

Gaur AH, Baltrusaitis K, Capparelli EV et al

Lancet HIV

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Acceptability and tolerability of long-acting injectable cabotegravir-rilpivirine in adolescents with HIV-1 (IMPAACT 2017/MOCHA): 48-week results of a multicentre, open-label, non-comparative phase 1/2 trial

Lowenthal ED, Chapman J, Baltrusaitis K et al

Lancet HIV

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Monitoring broadly neutralising HIV antibody concentrations using microsampling on dried blood spots in infants

Latour R, Mkhize NN, Debiesse S et al

Journal of Infection

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Genital tract infections, antiretroviral treatment and HIV-1 viral load in early postpartum women: implications for sexual and breastfeeding HIV transmission

Govender V, Govender K, Moodley D

BMC Infectious Diseases

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Evolution of the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones

Turner CT, Tiffeau-Mayer A, Rosenheim J et al

Nature Communications

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COVID-19 pandemic changes in social behavior relevant for transmission of Mycobacterium tuberculosis

Nelson KN, Harton P, Cohen T, Willis F, Yoshii H, Naidoo K et al

BMC Research Notes

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Comparing Respiratory Illness Surveillance Case Definitions to Detect Bordetella pertussis in Children Aged <5 Years With Respiratory Illness in South Africa, 2017-2023

Bishop K, Moosa F, Makhasi M et al

Journal of Infectious Diseases

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Trump one year on: How six US researchers plan to protect science amid chaos and cuts

Clark A, Greely H, Topol E, Abdool Karim SS, Abdool Karim Q, Laxminarayan R

Nature

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A 3-month clofazimine-rifapentine-containing regimen for drug-susceptible tuberculosis versus standard of care (Clo-Fast): a randomised, open-label, phase 2c clinical trial

Metcalfe JZ, Weir IR, Scarsi KK et al

Lancet Infectious Diseases

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Retrospective cohort analysis of antiretroviral therapy initiation timelines and clinical outcomes in adults with HIV and TB disease in KwaZulu-Natal, South Africa

Jansen van Vuuren CJ, van der Molen J, Sookrajh Y et al

International Journal of STD & AIDS

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Human rights limitations in global health law reforms

Sircar NR, Abdool Karim S, Forman L et al

Public Health

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Fixed-dose combination bictegravir-emtricitabine-tenofovir alafenamide twice-daily for treatment of HIV during rifampicin-based tuberculosis treatment (INSIGHT Study): a phase 2b, open-label, randomised non-comparative trial

Naidoo A, Naidoo K, Letsoalo MP et al

Lancet HIV

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Transmission of bedaquiline-resistant Mycobacterium tuberculosis in KwaZulu-Natal, South Africa

Sobol R, Omar SV, Brown TS et al

American Journal of Respiratory and Critical Care Medicine

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Tracking wildfire-documenting the spread of bedaquiline-resistant tuberculosis

Nimmo C, Perumal R, O'Donnell M

American Journal of Respiratory and Critical Care Medicine

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