Scientific Publications

V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity.
van Eeden C, Wibmer CK, Scheepers C, Richardson SI, Nonyane M, Lambson B, Mkhize NN, Vijayakumar B, Sheng Z, Stanfield-Oakley S, Bhiman JN, Bekker V, Hermanus T, Mabvakure B, Ismail A, Moody MA, Wiehe K, Garrett N, Abdool Karim SS, Dirr H, Fernandes MA, Sayed Y, Shapiro L, Ferrari G, Haynes BF, Moore PL, Morris L.
Cell Reports 2018; 25(11):3123-3135.

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Common helical V1V2 conformations of HIV-1 Envelope expose the alpha4beta7 binding site on intact virions.
Wibmer CK, Richardson SI, Yolitz J, Cicala C, Arthos J, Moore PL, Morris L.
Nature communications 2018; 9(1):4489.

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Tracking external introductions of HIV using phylodynamics reveals a major source of infections in rural KwaZulu-Natal, South Africa.
Rasmussen DA, Wilkinson E, Vandormael A, Tanser F, Pillay D, Stadler T, de Oliveira T.
Virus Evolution 2018; 4(2):vey037. doi: 10.1093/ve/vey037.

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Inflammatory Cytokine Profiles of Semen Influence Cytokine Responses of Cervicovaginal Epithelial Cells.
Rametse CL, Adefuye AO, Olivier AJ, Curry L, Gamieldien H, Burgers WA, Lewis DA, Williamson AL, Katz AA, Passmore JS.
Frontiers in immunology 2018; 9:2721. doi: 10.3389/fimmu.2018.02721.

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High-frequency, functional HIV-specific T-follicular helper and regulatory cells are present within germinal centers in children but not adults.
Roider J, Maehara T, Ngoepe A, Ramsuran D, Muenchhoff M, Adland E, Aicher T, Kazer SW, Jooste P, Karim F, Kuhn W, Shalek AK, Ndung'u T, Morris L, Moore PL, Pillai S, Kløverpris H, Goulder P, Leslie A.
Frontiers in immunology 2018; 9:1975. doi: 10.3389/fimmu.2018.01975.

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The adjuvant AlhydroGel elicits higher antibody titres than AddaVax when combined with HIV-1 subtype C gp140 from CAP256.
van Diepen MT, Chapman R, Moore PL, Margolin E, Hermanus T, Morris L,Ximba P, Rybicki EP, Williamson AL.
PLoS One 2018; 13(12):e0208310.

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The multi-country PROMOTE HIV antiretroviral treatment observational cohort in Sub-Saharan Africa: Objectives, design, and baseline findings.
Taha TE, Yende-Zuma N, Aizire J, Chipato T, Wambuzi Ogwang L, Makanani B, Chinula L, Nyati MM, Hanley S, Brummel SS, Fowler MG.
PLoS One 2018; 13(12):e0208805.

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Community engagement with HIV drug adherence in rural South Africa: a transdisciplinary approach.
Treffry-Goatley A, Lessells RJ, Moletsane R, de Oliveira T, Gaede B.
Medical Humanities 2018; 44(4):239-246.

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Sources of social support and sexual behaviour advice for young adults in rural South Africa
Harling G, Gumede D, Shahmanesh M, Pillay D, Barnighausen TW, Tanser F.
BMJ Glob Health 2018; 3(6):e000955.

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Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial.
Landovitz RJ, Li S, Grinsztejn B, Dawood H, Liu AY, Magnus M, Hosseinipour MC, Panchia R, Cottle L, Chau G, Richardson P, Marzinke MA, Hendrix CW, Eshleman SH, Zhang Y, Tolley E, Sugarman J, Kofron R, Adeyeye A, Burns D, Rinehart AR, Margolis D, Spreen WR, Cohen MS, McCauley M, Eron JJ.
PLoS Medicine 2018; 15(11):e1002690.

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"Why don't you go into suburbs? Why are you targeting us?": trust and mistrust in HIV vaccine trials in South Africa.
Thabethe S, Slack C, Lindegger G, Wilkinson A, Wassenaar D, Kerr P, Bekker LG, Mngadi K, Newman PA.
Journal of Empirical Research on Human Research Ethics 2018;13(5):525-536.

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Pregnancy and infant outcomes among women using the dapivirine vaginal ring in early pregnancy.
Makanani B, Balkus JE, Jiao Y, Noguchi LM, Palanee-Phillips T, Mbilizi Y, Moodley J, Kintu K, Reddy K, Kabwigu S, Jeenariain N, Harkoo I, Mgodi N, Piper J, Rees H, Scheckter R, Beigi R, Baeten JM.
JAIDS 2018; 79(5):566-572.

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Impact of partner-related social harms on women’s adherence to the dapivirine vaginal ring during a phase III trial.
Palanee-Phillips T, Roberts ST, Reddy K, Govender V, Naidoo L, Siva S, Gafoor Z, Pather A, Matovu F, Hlahla K, Makanani B, Nair G, Schwartz K, Torjesen K, Brown E, Soto-Torres L, Baeten J, Montgomery ET, on behalf of MTN-020/ASPIRE team.
JAIDS 2018; 79(5):580-589.

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Measuring the ability of HIV-specific antibodies to mediate trogocytosis.
Richardson SI, Crowther C, Mkhize NN, Morris L.
Journal of Immunological Methods 2018;463:71-83.

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To End TB, First-Ever High-Level Meeting on TB Must Address Stigma.
Daftary A, Mitchell EMH, Reid MJA, Fekadu E, Goosby E.
American Journal of Tropical Medicine and Hygiene 2018; 99(5):1114-1116.

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Effect of Antiretroviral Therapy on Treatment Outcomes in a Prospective Study of Extensively Drug Resistant Tuberculosis (XDR-TB) HIV Co-Infection Treatment in KwaZulu-Natal, South Africa.
Yuengling KA, Padayatchi N, Wolf A, Mathema B, Brown T, Horsburgh CR, O'Donnell MR.
Journal of Acquired Immune Deficiency Syndromes 2018; 79(4):474-480.

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Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation.
Johnson EL, Doria-Rose NA, Gorman J, Bhiman JN, Schramm CA, Vu AQ, Law WH, Zhang B, Bekker V, Abdool Karim SS, Ippolito GC, Morris L, Moore PL, Kwong PD, Mascola JR, Georgiou G.
Nature Communications 2018; 9(1):4136. doi: 10.1038/s41467-018-06424-6.

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Using Mobile Technology (pMOTAR) to Assess Reactogenicity: Protocol for a Pilot Randomized Controlled Trial.
Mngadi KT, Maharaj B, Duki Y, Grove D, Andriesen J.
JMIR research protocols 2018; 7(10):e175. doi: 10.2196/resprot.9396.

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A FRESH approach: Combining basic science and social good.
Ndung'u T, Dong KL, Kwon DS, Walker BD.
Science Immunology 2018; 3(27):eaau2798. doi: 10.1126/sciimmunol.aau2798.

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HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth.
Sheward DJ, Marais J, Bekker V, Murrell B, Eren K, Bhiman JN, Nonyane M, Garrett N, Woodman ZL, Abdool Karim Q, Abdool Karim SS, Morris L, Moore PL, Williamson C.
Cell Host Microbe 2018; 24(4):593-599.

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Maternal health outcomes among HIV-infected breastfeeding women with high CD4 counts: results of a treatment strategy trial
Hoffman RM, Angelidou KN, Brummel SS, Saidi F, Violari A, Dula D, Mave V, Fairlie L, Theron G, Kamateeka M, Chipato T, Chi BH, Stranix-Chibanda L, Nematadzira T, Moodley D, Bhattacharya D, Gupta A, Coletti A, McIntyre JA, Klingman KL, Chakhtoura N, Shapiro DE, Fowler MG, Currier JS; IMPAACT PROMISE 1077BF/FF team
HIV Clinical Trials 2018; 19(6):209-224

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Epidemiology and Molecular Identification and Characterization of Mycoplasma pneumoniae, South Africa, 2012-2015.
Carrim M, Wolter N, Benitez AJ, Tempia S, du Plessis M, Walaza S, Moosa F, Diaz MH, Wolff BJ, Treurnicht FK, Hellferscee O, Dawood H, Variava E, Cohen C, Winchell JM, von Gottberg A.
Emerging Infectious Diseases 2018;24(3):506-513.

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Targeting the third ‘90’: introducing the viral load champion.
Sunpath H, Hatlen TJ, Naidu KK, Msimango P, Adams RN, Moosa M-Y S, Marconi VC, Murphy RA, Gandhi RT, Pillay S, Siedner M, Naidoo K.
Public Health Action 2018; 8(4):225-231.

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Variation in the untranslated genome and susceptibility to infections.
Ramsuran V, Ewy R, Nguyen H, Kulkarni S.
Frontiers in Immunology. 2018 September; 9(Issue Sept): 2046. doi: 10.3389/fimmu.2018.02046.

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Addressing the tensions and complexities involved in commissioning and undertaking implementation research in low- and middle-income countries.
Doherty T, Lewin S, Kinney M, Sanders D, Mathews C, Daviaud E, Goga A, Bhana A, Besada D, Vanleeuw L, Loveday M, Odendaal W, Leon N.
BMJ Global Health 2018; 3(4):e000741.

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Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers.
Landais E, Moore PL.
Retrovirology 2018 September; 15(1):61. doi: 10.1186/s12977-018-0443-0.

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Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha4beta7.
Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J.
PLoS Pathogens 2018; 14(8):e1007278.

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Recurrent tuberculosis among HIV-coinfected patients: a case series from KwaZulu-Natal.
Naidoo K, Dookie N, Naidoo K, Yende-Zuma N, Chimukangara B, Bhushan A, Govender D, Gengiah S, Padayatchi N.
Infection and Drug Resistance 2018; 11:1413-1421.

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Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.
Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Frechet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborin R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, et al.
Lancet 2018; 392(10150):821-834.

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Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women.
Perciani CT, Sekhon M, Hundal S, Farah B, Ostrowski MA, Anzala AO, McKinnon LR, Walter J, MacDonald KS.
Journal of Infectious Diseases 2018; 218(8):1210-1218.

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Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression.
Tanko RF, Soares AP, Masson L, Garrett NJ, Samsunder N, Abddol Karim Q, Abdool Karim SS, Riou C, Burgers WA.
Clinical Immunology 2018; 195:127-138.

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Lower genital tract cytokine profiles in South African women living with HIV: influence of mucosal sampling.
Jaumdally SZ, Masson L, Jones HE, Dabee S, Hoover DR, Gamieldien H, Langwenya N, Myer L, Todd CS, Passmore JS.
Scientific reports. 2018 Aug;8(1):12203.

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HIV-1 Subtype C Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes.
Ditse Z, Muenchhoff M, Adland E, Jooste P, Goulder P, Moore PL, Morris L.
Journal of Virology 2018; 92(17): e00878-18.

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Resuscitation-Promoting Factors Are Required for Mycobacterium smegmatis Biofilm Formation.
Ealand C, Rimal B, Chang J, Mashigo L, Chengalroyen M, Mapela L, Beukes G, Machowski E, Kim SJ, Kana B.
Applied and Environmental Microbiology 2018; 84(17): e00687-18.

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Association between internal migration and epidemic dynamics: an analysis of cause-specific mortality in Kenya and South Africa using health and demographic surveillance data.
Ginsburg C, Bocquier P, Beguy D, Afolabi S, Kahn K, Obor D, Tanser F, Tomita A, Wamukoya M, Collinson MA.
BMC Public Health 2018; 18(1):918.

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Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection.
Balle C, Lennard K, Dabee S, Barnabas SL, Jaumdally SZ, Gasper MA, Maseko V, Mbulawa ZZA, Williamson AL, Bekker LG, Lewis DA, Passmore JS, Jaspan HB.
Scientific Reports 2018; 8(1):11109.

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Expert consensus statement on the science of HIV in the context of criminal law.
Barre-Sinoussi F, Abdool Karim SS, Albert J, Bekker LG, Beyrer C, Cahn P, Calmy A, Grinsztejn B, Grulich A, Kamarulzaman A, Kumarasamy N, Loutfy MR, El Filali KM, Mboup S, Montaner JS, Munderi P, Pokrovsky V, Vandamme AM, Young B, Godfrey-Faussett P.
Journal of the International AIDS Society 2018; 21(7):e25161.

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Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.
Drain PK, Bajema KL, Dowdy D, Dheda K, Naidoo K, Schumacher SG, Ma S, Meermeier E, Lewinsohn DM, Sherman DR.
Clinical Microbiology Reviews 2018; 31(4): e00021-18

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Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19).
Barouch DH*, Tomaka FL*, Wegmann F*, Stieh DJ, Alter G, Robb ML, Michael NL, Peter L, Nkolola JP, Borducchi EN, Chandrashekar A, Jetton D, Stephenson KE, Li W, Korber B, Tomaras GD, Montefiori DC, Gray G, Frahm N, McElrath MJ, Baden L, Johnson J, Hutter J, Swann E, Karita E, Kibuuka H, Mpendo J, Garrett N, Mngadi K, Chinyenze K, Priddy F, Lazarus E, Laher F, Nitayapan S, Pitisuttithum P, Bart S, Campbell T, Feldman R, Lucksinger G, Borremans C, Callewaert K, Roten R, Sadoff J, Scheppler L, Weijtens M, Feddes-de Boer K, van Manen D, Vreugdenhil J, Zahn R, Lavreys L, Nijs S, Tolboom J, Hendriks J, Euler Z, Pau MG, Schuitemaker H.
Lancet 2018; 392(10143):232-243.

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Perceived HIV-related stigma among university students in South Africa: implications for HIV testing.
Haffejee F, Maughan-Brown B, Buthelezi T, Kharsany ABM.
African Journal of AIDS Research 2018;17(2):109-118.

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Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.
Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, Seddon JA, Menzies D, Turkova A, Achar J, Amanullah F, Barry P, Becerra M, Chan ED, Chan PC, Ioana Chiotan D, Crossa A, Drobac PC, Fairlie L, Falzon D, Flood J, Gegia M, Hicks RM, Isaakidis P, Kadri SM, Kampmann B, Madhi SA, Marais E, Mariandyshev A, Mendez-Echevarria A, Moore BK, Nargiza P, Ozere I, Padayatchi N, Ur-Rehman S, Rybak N, Santiago-Garcia B, Shah NS, Sharma S, Shim TS, Skrahina A, Soriano-Arandes A, van den Boom M, van der Werf MJ, van der Werf TS, Williams B, Yablokova E, Yim JJ, Furin J, Hesseling AC; Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR-TB.
PLoS Medicine 2018; 15(7):e1002591. doi: 10.1371/journal.pmed.1002591.

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Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial.
Bekker L-G, Moodie Z, Grunenberg N, Laher F, Tomaras GD, Cohen KW, Allen M, Malahleha M, Mngadi K, Daniels B, Innes C, Bentley C, Frahm N, Morris DE, Morris L, Mkhize NN, Montefiori DC, Sarzotti-Kelsoe M, Grant S, Yu C, Mehra VL, Pensiero MN, Phogat S, DiazGranados CA, Barnett SW, Kanesa-thasan N, Koutsoukos M, Michael NL, Robb ML, Kublin JG, Gilbert PB, Corey L, Gray GE, McElrath MJ, on behalf of the HVTN 100 Protocol Team.
Lancet HIV 2018; 5(7):e366–e378.

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Vaginal microbiomes associated with aerobic vaginitis and bacterial vaginosis.
Kaambo E, Africa C, Chambuso R, Passmore JS.
Front Public Health 2018; 6:78. doi: 10.3389/fpubh.2018.00078.

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Whole-Genome Sequencing to Guide the Selection of Treatment for Drug-Resistant Tuberculosis.
Dookie N, Naidoo K, Padayatchi N.
Antimicrobial Agents and Chemotherapy 2018; 62(8). e00574-18. doi: 10.1128/AAC.00574-18.

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Genomic and epidemiological monitoring of yellow fever virus transmission potential
Faria NR, Kraemer MUG, Hill SC, Goes de Jesus J, Aguiar RS, Iani FCM, Xavier J, Quick J, du Plessis L, Dellicour S, Theze J, Carvalho RDO, Baele G, Wu CH, Silveira PP, Arruda MB, Pereira MA, Pereira GC, Lourenco J, Obolski U, Abade L, Vasylyeva TI, Giovanetti M, Yi D, Weiss DJ, Wint GRW, Shearer FM, Funk S, Nikolay B, Fonseca V, Adelino TER, Oliveira MAA, Silva MVF, Sacchetto L, Figueiredo PO, Rezende IM, Mello EM, Said RFC, Santos DA, Ferraz ML, Brito MG, Santana LF, Menezes MT, Brindeiro RM, Tanuri A, Dos Santos FCP, Cunha MS, Nogueira JS, Rocco IM, da Costa AC, Komninakis SCV, Azevedo V, Chieppe AO, Araujo ESM, Mendonca MCL, Dos Santos CC, Dos Santos CD, Mares-Guia AM, Nogueira RMR, Sequeira PC, Abreu RG, Garcia MHO, Abreu AL, Okumoto O, Kroon EG, de Albuquerque CFC, Lewandowski K, Pullan ST, Carroll M, de Oliveira T, Sabino EC, Souza RP, Suchard MA, Lemey P, Trindade GS, Drumond BP, Filippis AMB, Loman NJ, Cauchemez S, Alcantara LCJ, Pybus OG
Science 2018; 361(6405):894-899.

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Community-based HIV prevalence in KwaZulu-Natal, South Africa: results of a cross-sectional household survey.
Kharsany ABM, Cawood C, Khanyile D, Lewis L, Grobler A, Puren A, Govender K, George G, Beckett S, Samsunder N, Madurai S, Toledo C, Chipeta Z, Glenshaw M, Hersey S, Abdool Karim Q.
Lancet HIV 2018 Lancet HIV 2018; 5(8):e427-e437

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Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research.
Dorward J, Lessells R, Drain PK, Naidoo K, de Oliveira T, Pillay Y, Abdool Karim SS, Garrett N.
Lancet HIV 2018; 5(7): e400–e404.

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Ex vivo HIV entry into blood CD4+ T cells does not predict heterosexual HIV acquisition in women.
Joag V, Sivro A, Yende-Zuma N, Imam H, Samsunder N, Abdool Karim Q, Abdool Karim S, McKinnon L, Kaul R
PLoS One 2018; 13(7):e0200359.

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Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults.
Bisson GP, Ramchandani R, Miyahara S, Mngqibisa R, Matoga M, Ngongondo M, Samaneka W, Koech L, Naidoo K, Rassool M, Kirui F, Banda P, Mave V, Kadam D, Leger P, Henostroza G, Manabe YC, Bao J, Kumwenda J, Gupta A, Hosseinipour MC; Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team.
AIDS 2017; 31(16):2217-25.

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HIV-No time for complacency
Abdool Karim Q, Abdool Karim SS.
Science 2018; 360(6394):1153. DOI: 10.1126/science.aau2663.

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Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.
Setliff I, McDonnell WJ, Raju N, Bombardi RG, Murji AA, Scheepers C, Ziki R, Mynhardt C, Shepherd B, Mamchak AA, Garrett N, Abdool Karim SS, Mallal SA, Crowe JE, Morris L, Georgiev IS.
Cell Host & Microbe 2018; 23(6):845-854.

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Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group(dagger).
James S, Collins FH, Welkhoff PA, Emerson C, Godfray HCJ, Gottlieb M, Greenwood B, Lindsay SW, Mbogo CM, Okumu FO, Quemada H, Savadogo M, Singh JA, Tountas KH, Toure YT.
The American Journal of Tropical Medicine and Hygiene 2018;98Suppl 6):1-49.

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HIV Treatment Substantially Decreases Hospitalization Rates: Evidence From Rural South Africa.
Hontelez JA, Bor J, Tanser F, Pillay D, Moshabela M, Bärnighausen T.
Health Affairs 2018; 37(6):997-1004.

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HIV risk among adolescent girls and young women in age-disparate partnerships: Evidence from KwaZulu-Natal, South Africa.
Maughan-Brown B, George G, Beckett S, Evans M, Lewis L, Khanyile D, Kharsany ABM.
Journal of Acquired Immune Deficiency Syndromes 2018; 78(2):155-162.

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Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV.
Barnabas SL, Dabee S, Passmore JS, Jaspan HB, Lewis DA, Jaumdally SZ, Gamieldien H, Masson L, Muller E, Maseko VD, Mkhize N, Mbulawa Z, Williamson AL, Gray CM, Hope TJ, Chiodi F, Dietrich J, Gray G, Bekker LG; Women’s Initiative in Sexual Health (WISH) study team.
International Journal of STD & AIDS 2018; 29(6):531-539.

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List randomization for eliciting HIV status and sexual behaviors in rural KwaZulu-Natal, South Africa: a randomized experiment using known true values for validation.
Haber N, Harling G, Cohen J, Mutevedzi T, Tanser F, Gareta D, Herbst K, Pillay D, Barnighausen T, Fink G.
BMC Medical Research Methodology 2018; 18(1):46. doi: 10.1186/s12874-018-0507-9.

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Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.
McKinnon LR, Liebenberg LJ, Yende-Zuma N, Archary D, Ngcapu S, Sivro A, Nagelkerke N, Garcia Lerma JG, Kashuba AD, Masson L, Mansoor LE, Abdool Karim Q, Abdool Karim SS, Passmore JS.
Nature Medicine 2018; 24(4):491-496.

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Acceptability of early antiretroviral therapy among South African women
Garrett N, Norman E, Leask K, Naicker N, Asari V, Majola N, Abdool Karim Q, Abdool Karim SS
AIDS and Behavior 2018; 22(3):1018-1024

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Training social workers to enhance patient-centered care for drug-resistant TB-HIV in South Africa
Zelnick JR, Seepamore B, Daftary A, Amico KR, Bhengu X, Friedland G, Padayatchi N, Naidoo K, O'Donnell MR
Public Health Action 2018; 8(1):25-27

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Targeting the right interventions to the right people and places: the role of geospatial analysis in HIV program planning.
Meyer-Rath G, McGillen JB, Cuadros DF, Hallett TB, Bhatt S, Wabiri N, Tanser F, Rehle T.
AIDS 2018; 32(8):957-963.

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Reasons for nonadherence to the dapivirine vaginal ring: narrative explanations of objective drug-level results
Montgomery ET, Stadler J, Naidoo S, Katz A, Laborde N, Garcia M, Reddy K, Mansoor LE, Etima J, Zimba C, Chitukuta M, Soto-Torres L.
AIDS 2018; 32(11):1517-1525.

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Clinic flow for STI, HIV, and TB patients in an urban infectious disease clinic offering point-of-care testing services in Durban, South Africa.
Stime KJ, Garrett N, Sookrajh Y, Dorward J, Dlamini N, Olowolagba A, Sharma M, Barnabas RV, Drain PK.
BMC Health Services Research 2018; 18(1):363. doi: 10.1186/s12913-018-3154-2.

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Evolution of drug resistance in Mycobacterium tuberculosis: A review on the molecular determinants of resistance and implications for personalized care.
Dookie N, Rambaran S, Padayatchi N, Mahomed S, Naidoo K.
Journal of Antimicrobial Chemotherapy 2018; 73(5):1138-1151.

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Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B* 57 protection against HIV-1.
Martin MP, Naranbhai V, Shea PR, Qi Y, Ramsuran V, Vince N, Gao X, Thomas R, Brumme ZL, Carlson JM, Wolinsky SM, Goedert JJ, Walker BD, Segal FP, Deeks SG, Haas DW, Migueles SA, Connors M, Michael N, Fellay J, Gostick E, Llewellyn-Lacey S, Price DA, Lafont BA, Pymm P, Saunders PM, Widjaja J, Wong SC, Vivian JP, Rossjohn J, Brooks AG, Carrington M.
The Journal of Clinical Investigation 2018; 128(5):1903-1912.

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Renewing Felsenstein's phylogenetic bootstrap in the era of big data.
Lemoine F, Domelevo Entfellner JB, Wilkinson E, Correia D, Davila Felipe M, De Oliveira T, Gascuel O.
Nature 2018; 556:452-456.

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Palliative care for drug-resistant tuberculosis: An urgent call to action.
Govender T, Naidoo S, Padayatchi N, Gwyther L.
South African Medical Journal 2018; 108(5):360.

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MDR-TB patients in KwaZulu-Natal, South Africa: Cost-effectiveness of 5 models of care.
Loveday M, Wallengren K, Reddy T, Besada D, Brust JC, Voce A, Desai H, Ngozo J, Radebe Z, Master I, Padayatchi N, Daviaud E.
PloS One 2018; 13(4): e0196003.

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Beyond syndromic management: Opportunities for diagnosis-based treatment of sexually transmitted infections in low- and middle-income countries.
Garrett NJ, Osman F, Maharaj B, Naicker N, Gibbs A, Norman E, Samsunder N, Ngobese H, Mitchev N, Singh R, Abdool Karim SS, Kharsany ABM, Mlisana K, Rompalo A, Mindel A.
PLoS One 2018; 13(4):e0196209.

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Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa.
Bionghi N, Daftary A, Maharaj B, Msibi Z, Amico KR, Friedland G, Orrell C, Padayatchi N, O'Donnell MR.
BMC Infectious Diseases 2018; 18(1):171.

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Mortality and treatment response amongst HIV-infected patients 50 years and older accessing antiretroviral services in South Africa.
Dawood H, Hassan-Moosa R, Yende-Zuma N, Naidoo K.
BMC Infectious Diseases 2018; 18(1):168. doi: 10.1186/s12879-018-3083-z.

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HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies.
Richardson SI, Chung AW, Natarajan H, Mabvakure B, Mkhize NN, Garrett N, Abdool Karim SS, Moore PL, Ackerman ME, Alter G, Morris L.
PLoS Pathogens 2018; 14(4): e1006987. doi: 10.1371/journal.ppat.1006987.

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Longitudinal trends in the prevalence of detectable HIV viremia: Population-based evidence from rural KwaZulu-Natal, South Africa.
Vandormael A, Bärnighausen T, Herbeck J, Tomita A, Phillips A, Pillay D, de Oliveira T, Tanser F.
Clinical Infectious Diseases 2018; 66(8):1254-1260.

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Clinic-Based Evaluation of A Point-Of-Care Creatinine Assay to Screen for Renal Impairment Amongst Hiv-Positive Patients Receiving Tenofovir Disoproxil Fumarate.
Dorward J, Yende-Zuma N, Samsunder N, Abdool Karim Q, Drain PK, Garrett N.
JAIDS 2018; 77(4):e36-e39. doi: 10.1097/QAI.0000000000001613.

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Prevention of HIV-1 transmission through breastfeeding: efficacy and safety of maternal antiretroviral therapy versus infant Nevirapine Prophylaxis for duration of breastfeeding in HIV-1-infected women with high CD4 Cell count (Impaact Promise): A randomized, open label, clinical trial.
Flynn PM, Taha TE, Cababasay M, Fowler MG, Mofenson LM, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanashanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S, Vhembo T, Bobat R, Mmbaga BT, Masenya M, Nyati M, Theron G, Mulenga H, Butler K, Shapiro DE.
Journal of Acquired Deficiency Syndromes 2018; 77(4):383-392.

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Impact of an educational video as a consent tool on knowledge about cure research among patients and caregivers at HIV clinics in South Africa.
Hendricks M, Nair G, Staunton C, Pather M, Garrett N, Baatjies D, Kidd M, Moodley K.
Journal of Virus Eradication 2018; 4(2):103-107.

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TB epidemiology: where are the young women? Know your tuberculosis epidemic, know your response.
Perumal R, Naidoo K, Padayatchi N.
BMC Public Health 2018; 18(1):417. doi: 10.1186/s12889-018-5362-4.

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Acceptability of early antiretroviral therapy among South African women.
Garrett N, Norman E, Leask K, Naicker N, Asari V, Majola N, Abdool Karim Q, and Abdool Karim SS.
AIDS and Behavior 2018; 22(3):1018-1024.

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Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death.
Jackson L, Hunter J, Cele S, Ferreira IM, Young AC, Karim F, Madansein R, Dullabh KJ, Chen CY, Buckels NJ, Ganga Y, Khan K, Boulle M, Lustig G, Neher RA, Sigal A.
eLife 2018; 7:e30134. doi: 10.7554/eLife.30134

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HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis.
Gupta RK, Gregson J, Parkin N, Haile-Selassie H, Tanuri A, Andrade Forero L, Kaleebu P, Watera C, Aghokeng A, Mutenda N, Dzangare J, Hone S, Hang ZZ, Garcia J, Garcia Z, Marchorro P, Beteta E, Giron A, Hamers R, Inzaule S, Frenkel LM, Chung MH, de Oliveira T, Pillay D, Naidoo K, Kharsany A, Kugathasan R, Cutino T, Hunt G, Avila Rios S, Doherty M, Jordan MR, Bertagnolio S.
Lancet Infectious Diseases 2018; 18(3):346-355.

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Neutralization tiers of HIV-1.
Montefiori DC, Roederer M, Morris L, Seaman MS.
Current Opinion in HIV and AIDS 2018; 13(2):128-136.

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Considerations for biomarker-targeted intervention strategies for TB prevention.
Fiore-Gartland A, Carpp LN, Naidoo K, Thompson E, Zak DE, Self S, Churchyard G, Walzl G, Penn-Nicholson A, Scriba TJ, Hatherill M.
Tuberculosis 2018; 109: 61-68.

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Spatial clustering of drug-resistant tuberculosis in Hlabisa subdistrict, KwaZulu-Natal, 2011-2015.
Smith CM, Lessells R, Grant AD, Herbst K, Tanser F.
International Union against Tuberculosis and Lung Disease 2018; 22(3):287-293.

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Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe.
Kamariza M, Shieh P, Ealand CS, Peters JS, Chu B, Rodriguez-Rivera FP, Sait MR, Treuren WV, Martinson N, Kalscheuer R, Kana BD.
Science Translational Medicine 2018; 10(430):eaam6310. doi: 10.1126/scitranslmed.aam6310.

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Mobility and increased risk of HIV acquisition in South Africa: a mixed-method systematic review protocol.
Dzomba A, Govender K, Mashamba-Thompson TP, Tanser F.
Systematic Reviews 2018; 7(1):37. doi: 10.1186/s13643-018-0703-z.

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Weighing in on the risks and benefits of probiotic use in HIV-infected and immunocompromised populations.
Happel AU, Barnabas SL, Froissart R, Passmore JS.
Beneficial Microbes 2018; 9(2):239-246.

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Risk Compensation Following Medical Male Circumcision: Results from a 1-Year Prospective Cohort Study of Young School-Going Men in KwaZulu-Natal, South Africa.
Govender K, George G, Beckett S, Montague C, Frohlich J.
International Journal of Behavioral Medicine 2018; 25(1):123-130.

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Acceptability of HIV Self-Testing in Sub-Saharan Africa: Scoping Study.
Harichund C, Moshabela M.
AIDS and Behavior 2018; 22(2):560-568.

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Identification and validation of a multi‐assay algorithm for cross‐sectional HIV incidence estimation in populations with subtype C infection.
Laeyendecker O, Konikoff J, Morrison DE, Brookmeyer R, Wang J, Celum C, Morrison CS, Abdool Karim Q, Pettifor AE, Eshleman SH
Journal of the International AIDS Society 2018; 21(2):e25082. doi: 10.1002/jia2.25082.

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Impact of the scale-up of piped water on urogenital schistosomiasis infection in rural South Africa.
Tanser F, Azongo DK, Vandormael A, Bärnighausen T, Appleton C.
eLife. 2018; 7: e33065. doi: 10.7554/eLife.33065.

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HLA class I-mediated HIV-1 control in Vietnamese infected with HIV-1 subtype A/E.
Chikata T, Van Tran G, Murakoshi H, Akahoshi T, Qi Y, Naranbhai V, Kuse N, Tamura Y, Koyanagi M, Sakai S, Nguyen DH, Nguyen DT, Nguyen HT, Nguyen TV, Oka S, Martin MP, Carrington M, Sakai K, Van Nguyen K, Takiguchi M.
Journal of Viroloy 2018; 92(5). pii: e01749-17. doi: 10.1128/JVI.01749-17.

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Training social workers to enhance patient-centered care for drug-resistant TB-HIV in South Africa.
Zelnick JR, Seepamore B, Daftary A, Amico KR, Bhengu X, Friedland G, Padayatchi N, Naidoo K, O'Donnell MR.
Public Health Action 2018 March; 8(1):25-27.

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High percentage of undiagnosed HIV cases within a hyperendemic South African community: a population-based study.
Vandormael A, de Oliveira T, Tanser F, Barnighausen T, Herbeck JT.
Journal of Epidemiol Community Health 2018; 72(2):168-172

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Evaluation of a synthetic peptide for the detection of anti-Mycobacterium tuberculosis curli pili IgG antibodies in patients with pulmonary tuberculosis.
Naidoo N, Pillay B, Bubb M, Pym A, Chiliza T, Naidoo K, Ndungù T, Kasprowicz V, Pillay M.
Tuberculosis 2018; 109:80-84.

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Incidence rate estimation, periodic testing and the limitations of the mid-point imputation approach.
Vandormael A, Dobra A, Barnighausen T, de Oliveira T, Tanser F.
International Journal of Epidemiology 2018; 47(1):236-245.

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Case report: mechanisms of HIV elite control in two African women.
Moosa Y, Tanko RF, Ramsuran V, Singh R, Madzivhandila M, Yende-Zuma N, Abrahams MR, Selhorst P, Gounder K, Moore PL, Williamson C, Abdool Karim SS, Garrett NJ, Burgers WA.
BMC infectious diseases 2018;18(1):54. doi: 10.1186/s12879-018-2961-8.

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Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage.
Reh L, Magnus C, Kadelka C, Kühnert D, Uhr T, Weber J, Morris L, Moore PL, Trkola A.
PLoS pathogens 2018; 14(1):e1006825. doi: 10.1371/journal.ppat.1006825.

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HIV-1 superinfection can occur in the presence of broadly neutralizing antibodies.
Serwanga J, Ssemwanga D, Muganga M, Nakiboneka R, Nakubulwa S, Kiwuwa-Muyingo S, Morris L, Redd AD, Quinn TC, Kaleebu P, HIV Superinfection Study Group.
Vaccine 2018; 36(4):578-586.

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Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.
Sivro A, Schuetz A, Sheward D, Joag V, Yegorov S, Liebenberg LJ, Yende-Zuma N, Stalker A, Mwatelah RS, Selhorst P, Garrett N, Samsunder N, Balgobin A, Nawaz F, Cicala C, Arthos J, Fauci AS, Anzala AO, Kimani J, Bagaya BS, Kiwanuka N, Williamson C, Kaul R, Passmore JS, Phanuphak N, Ananworanich J, Ansari A, Abdool Karim Q, Abdool Karim SS, McKinnon LR, on behalf of the CAPRISA004 and RV254 study groups.
Science Translational Medicine 2018; 10(425): eaam6354. DOI: 10.1126/scitranslmed.aam6354.

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Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.
Naidoo A, Ramsuran V, Chirehwa M, Denti P, McIlleron H, Naidoo K, Yende-Zuma N, Singh R, Ngcapu S, Chaudhry M, Pepper MS, Padayatchi N.
Pharmacogenomics 2018;19(1):17-29.

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The Microbiome and HIV Prevention Strategies in Women.
Abdool Karim SS, Passmore J-AS, Baxter C.
Current Opinion in HIV and AIDS 2018; 13(1):81–87.

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Prevalence of skin diseases treated at public referral hospitals in KwaZulu-Natal, South Africa.
Dlova NC, Chateau A, Khoza N, Skenjane A, Mkhize M, Katibi OS, Grobler A, Gwegweni JT, Mosam A.
British Journal Dermatology 2018; 178(1):e1-e2. doi: 10.1111/bjd.15534.

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Point-of-care viral load testing and differentiated HIV care.
Dorward J, Drain PK, Garrett N.
Lancet HIV 2018; 5(1): e8-e9.

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Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.
Ramsuran V, Naranbhai V, Horowitz A, Qi Y, Martin MP, Yuki Y, Gao X, Walker-Sperling V, Del Prete GQ, Schneider DK, Lifson JD, Fellay J, Deeks SG, Martin JN, Goedert JJ, Wolinsky SM, Michael NL, Kirk GD, Buchbinder S, Haas D, Ndung'u T, Goulder P, Parham P, Walker BD, Carlson JM, Carrington M.
Science 2018; 359(6371):86-90.

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High human papillomavirus (HPV) prevalence in South African adolescents and young women encourages expanded HPV vaccination campaigns.
Mbulawa ZZ, van Schalkwyk C, Hu NC, Meiring TL, Barnabas S, Dabee S, Jaspan H, Kriek JM, Jaumdally SZ, Muller E, Bekker LG, Lewis DA, Dietrich J, Gray G, Passmore JS, Williamson AL.
PLoS One 2018; 13(1):e0190166.

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Vaginal microbes, inflammation, and HIV risk in African women.
Passmore J-AS, Jaspan HB.
Lancet Infectious Diseases 2018; 18(5):483-484.

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