Scientific Publications

Advances in childhood immunisation in South Africa: where to now? Programme managers' views and evidence from systematic reviews
Wiysonge CS, Ngcobo NJ, Jeena PM, Madhi SA, Schoub BD, Hawkridge A, Shey MS, Hussey GD
BMC Public Health 2012, 12:578

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Sustainability of task-shifting for antiretroviral treatment
Naranbhai V, Abdool Karim Q, Naidoo K, Yende-Zuma N, Abdool Karim SS
Lancet 2012; 380(9857):1907-8

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Mucosal Escherichia coli Bactericidal Activity and Immune Mediators Are Associated With HIV-1 Seroconversion in Women Participating in the HPTN 035 Trial.
Dezzutti CS, Richardson BA, Marrazzo JM, Tugetman J, Ramjee G, Taha T, Chirenje ZM, Abdool Karim SS, Hillier SL, Herold BC, on behalf of the MTN Biomedical Sciences Working Group and the HPTN 035 Protocol Team.
Journal of Infectious Disease 2012 Dec; 206(12):1931-5.

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Innate Immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel.
Naranbhai V, Abdool Karim SS, Altfeld M, Samsunder N, Durgiah R, Sibeko S, Abdool Karim Q, Carr WH.
Journal of Infectious Diseases 2012; 206(7):993-1001.

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Health in South Africa: changes and challenges since 2009.
Mayosi BM, Lawn JE, van Niekerk A, Bradshaw D, Abdool Karim SS, Coovadia HM.
Lancet 2012; 380(9858):2029-43.

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Lessons from a randomised clinical trial for multidrug-resistant tuberculosis.
Padayatchi N, Mac Kenzie WR, Hirsch-Moverman Y, Feng PJ, Villarino E, Saukkonen J, Heilig CM, Weiner M, El-Sadr WM.
International Journal of Tuberculosis and Lung Diseases 2012;16(12):1582-7.

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Temporal association of HLA-B*81:01 and B*39:10 mediated HIV-1 p24 sequence evolution with disease progression.
Ntale R, Chopera D, Ngandu N, Assis de Rosa D, Mlotshwa M, Werner L, Woodman Z, Mlisana K, Abdool Karim S, Gray C, Williamson C, and the CAPRISA 002 Study Team.
Journal of Virology 2012; 86(22):12013-24.

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Evolution of an HIV glycan-dependent broadly 1 neutralizing antibody 2 epitope through immune escape.
Moore PL, Gray ES, Wibmer CK, Bhiman JN, Nonyane M, Sheward DJ, Hermanus T, Bajimaya S, Tumba NL, Abrahams M-R, Lambson BE, Ranchobe N, Ping L, Ngandu N, Abdool Karim Q, Abdool Karim SS, Swanstrom RH, Seaman MS, Williamson C, Morris L.
Nature Medicine 2012; 18(11):1688-92.

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Understanding methods for estimating HIV-associated maternal mortality.
Rosen JE, de Zoysa I, Dehne K, Mangiaterra V, Abdool Karim Q
Journal of Pregnancy 2011; 2012: doi:10.1155/2012/958262

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Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.
Archary D, Rong R, Gordon ML, Boliar S, Madiga M, Gray ES, Dugast AS, Hermanus T, Goulder PJ, Coovadia HM, Werner L, Morris L, Alter G, Derdeyn CA, Ndung'u T.
Virology 2012; 433(2):410-420.

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Natural Killer cell function in women at high risk for HIV acquisition: Insights from the CAPRISA 004 microbicide trial.
Naranbhai V, Altfeld M, Abdool Karim Q, Ndung'u T, Abdool Karim SS, Carr WH; on behalf of the CAPRISA 004 TRAPS Team.
AIDS 2012; 26(14):1745-53.

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The Immune Reconstitution Inflammatory Syndrome After Antiretroviral Therapy Initiation in Patients With Tuberculosis: Findings From the SAPiT Trial.
Naidoo K, Yende-Zuma N, Padayatchi N, Naidoo K, Jithoo N, Nair G, Bamber S, Gengiah S, El-Sadr W, Friedland G, Abdool Karim SS.
Annals of Internal Medicine 2012;157(5):313-324.

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Tuberculosis among adults starting antiretroviral therapy in South Africa: The need for routine case finding.
Hanifa Y, Fielding KL, Charalambous S, Variava E, Luke B, Churchyard GJ, Grant AD.
International Journal of Tuberculosis and Lung Disease 2012; 16(9):1252-1259.

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Phase I safety and immunogenicity evaluations of an alphavirus replicon HIV-1 subtype C gag vaccine (AVX101) in healthy HIV-1 uninfected adults.
Wecker M, Gilbert P, Russell N, Hural J, Allen M, Pensiero M, Chulay J, Chiu Y-L, Abdool Karim S, Burke D.
Clinical and Vaccine Immunology 2012;19(10):1651-60.

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Utility of colposcopy in a phase 2 portion of a microbicide clinical trial of BufferGel and 0.5% PRO 2000 Gel.
Chirenje ZM, Masse BR, Maslankowski LA, Ramjee G, Coletti AS, Tembo TN, Magure TM, Soto-Torres L, Kelly C, Hillier S, Abdool Karim SS.
Journal of the International AIDS Society 2012; 15(2):17376.

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Preexposure Prophylaxis for HIV Prevention Recommend Initiating PrEP.
Abdool Karim SS, Gray GE, Martinson N.
New England Journal of Medicine 2012; 367(5):462-5.

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Pulmonary Resection for Extensively Drug Resistant Tuberculosis in Kwazulu-Natal, South Africa.
Iddriss A; Padayatchi N; Reddy D, Reddi A.
Annals of Thoracic Surgery 2012; 94(2):381-386.

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Advances in childhood immunisation in South Africa: where to now?
Wiysonge CS, Ngcobo NJ, Jeena PM, Madhi SA, Schoub BD, Hawkridge A, Shey MS, Hussey GD.
BMC Public Health 2012, 12:578 doi:10.1186/1471-2458-12-578.

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An AIDS-Free Generation?
Abdool Karim SS Science 2012; 337: 133.

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Experience of the HIV Prevention Trials Network HPTN.
Sista ND, Abdool Karim Q, Hinson S, Donnell D, Eshleman, Vermund SH. Development of an international network for clinical research

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The influence of tuberculosis treatment on efavirenz clearance in patients co-infected with HIV and tuberculosis.
Gengiah TN, Holford NH, Botha JH, Gray AL, Naidoo K, Abdool Karim SS.
European Journal of Clinical Pharmacology 2012; 68(5):689-95.

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Key issues in the clinical development and implementation of TB vaccines in South Africa.
Rustomjee R, Mcleod R, Hanekom W, Steel G, Mahomed H, Hawkridge A, Welte A, Sinanovic E, Loots G, Grobler A, Mvusi L, Gray G, Hesseling A, Ginsberg A, Lienhardtm C, Shea J, Tong X, Lockhart S, Churchyard GJ.
Tuberculosis 2012; 92(5):359-64.

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Why human health and health ethics must be central to climate change deliberations.
Singh JA.
PLoS Medicine 2012; 9(6):e1001229. doi:10.1371/journal.pmed.1001229.

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Preservation HIV-1-specific IFNγ+ CD4+ T cell responses in breakthrough infections following exposure to Tenofovir Gel in the CAPRISA 004 microbicide trial.
Mureithi MW, Poole D, Naranbhai V, Reddy S, Mkhwanazia NP, Sibeko S, Werner L, Abdool Karim Q, Abdool Karim S, Ndung’u T, Altfeld M and the CAPRISA004 Trial Group.
JAIDS 2012; 60(2):124–127.

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A community officers’ perspective of a rural hospital in KwaZulu-Natal
Perumal R, Padayatchi N South African Medical Journal 2012; 102(6): 355

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Antiretroviral prophylaxis for HIV prevention reaches a key milestone
Abdool Karim SS, Abdool Karim Q.
Lancet 2012; 379: 2047-2048.

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The Development of CD4 Binding Site Antibodies During HIV-1 Infection.
Lynch R, Tran L, Louder M, Cohen M, DerSimonian R, Euler Z, Gray E, Abdool Karim S, Kirchherr J, Montefiori D, Sibeko S, Soderberg K, Tomaras G, Yang Z-Y, Nabel G, Schuitemaker H, Morris L, Haynes B, Mascola J.
Journal of Virology 2012; 86(14):7588-7595.

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Population Pharmacokinetics and Pharmacodynamics of Ofloxacin in South African Patients With Multi-Drug Resistant Tuberculosis.
Chigutsa E, Meredith E, Wiesner L, Padayatchi N, Harding J, Moodley P, Mac Kenzie W, Weiner M, McIlleron H, Kirkpatrick C.
Antimicrobial Agents and Chemotherapy 2012; 56(7):3857-3863.

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CAPRISA 004 Tenofovir Microbicide Trial: No Impact of Tenofovir Gel on the HIV Transmission Bottleneck.
Valley-Omar Z, Sibeko S, Anderson J, Goodier S, Werner L, Arney L, Naranbhai V, Treurnicht F, Abrahams M-R, Bandawe G, Swanstrom R, Abdool Karim Q, Abdool Karim SS, Williamson C.
Journal of Infectious Diseases 2012; 206(1):35-40.

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Understanding methods for estimating HIV-associated maternal mortality.
Rosen JE, de Zoysa I, Dehne K, Mangiaterra V, Abdool Karim Q.
Journal of Pregnancy 2011; 2012: doi:10.1155/2012/958262.

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Pregnancy Incidence and Correlates during the HVTN 503 Phambili HIV Vaccine Trial Conducted among South African Women
Latka MH, Fielding K, Gray GE, Bekker L-G, Nchabeleng M, Mlisana K, Nielson T, Roux S, Mkhize B, Mathebula M, Naicker N, de Bruyn G, Kublin J, Churchyard GJ, on behalf of the HVTN 503 Phambili study team.
PLoS One 7(4): e31387.

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Symptomatic Vaginal Discharge Is a Poor Predictor of Sexually Transmitted Infections and Genital Tract Inflammation in High-Risk Women in South Africa
Mlisana K, Naicker N, Werner L, Roberts L, van Loggerenberg F, Baxter C, Passmore J-AS, Grobler AC, Sturm W, Williamson C, Ronacher K, Walzl G, Abdool Karim SS.
Journal of Infectious Diseases 2012; 206(1): 6-14.

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Implementing microbicides in low-income countries
Gengiah T, Abdool Karim Q Best Practice & Research Clinical Obstetrics & Gynaecology 2012; 26: 495-501

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Effects of a reduced dose of stavudine on the incidence and severity of peripheral neuropathy in HIV-infected adults in South Africa.
Pahuja M, Grobler A, Glesby MJ, Karim F, Parker G, Gumede S, Naidoo K.
Antiviral Therapy 2012; 17(4):737-743.

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Vaginal microbicides to prevent human immunodeficiency virus infection in women: perspectives on the female genital tract, sexual maturity and mucosal inflammation.
Roberts L, Liebenberg L, Barnabas S, Passmore JA.
Best Pract Res Clin Obstet Gynaecology 2012 August; 26(4):441-449. DOI: 10.1016/j.bpobgyn.2012.02.002.

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Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
Chopera DR, Cotton LA, Zawaira A, Mann JK, Ngandu NK, Ntale R, Carlson JM, Mlisana K, Woodman Z, de Assis Rosa D, Martin E, Miura T, Pereyra F, Walker BD, Gray CM, Martin DP, Ndung'u T, Brockman MA, Abdool Karim S, Brumme ZL, Williamson C; CAPRISA 002 Study Team.
Journal of Virology 2012;86(24):13423-33.

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Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells.
Riou C, Treurnicht F, Abrahams M-R, Mlisana K, Liu M, Goonetilleke N, Treurnicht F, Koup R, Roederer M, Abdool Karim S, De Bruyn G, Williamson C, Gray C.
Journal of Immunology 2012; 189(8):3838-47.

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Overview of microbicides for the prevention of human immunodeficiency virus.
Abdool Karim SS, Baxter C.
Best Pract Res Clin Obstet Gynaecol. 2012 Aug; 26(4):427-39.

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HIV Incidence in Young Girls in KwaZulu-Natal, South Africa-Public Health Imperative for Their inclusion in HIV Biomedical Intervention Trials.
Abdool Karim Q, Kharsany ABM, Frohlich JA, Werner L, Mlotshwa M, Madlala BT, Abdool Karim SS.
AIDS and Behavior 2012; 16(7):1870-6.

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A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.
Gengiah TN, Baxter C, Mansoor LE, Kharsany ABM, Abdool Karim SS.
Expert Opinion on Investigational Drugs 2012; 21(5):695-715.

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Drug Resistance and Coreceptor Usage in HIV-1 Subtype C Infected Children Initiating or Failing HAART in South Africa.
Green TN, Archary M, Gordon ML, Padayatchi N, Lie Y, Anton ED, Reeves JD, Grobler A, Bobat R, Coovadia H, Ndung'u T.
AIDS and Human Retroviruses 2012; 28(4):324-32

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Contraception and pregnancy in microbicide trials.
Sibeko S, Cohen GM, Moodley J.
Best Pract Res Clin Obstet Gynaecology 2012; 26(4): 473-486.

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Empowering women in human immunodeficiency virus prevention
Abdool Karim Q, Humphries H, Stein Z.
Best Pract Res Clin Obstet Gynaecology 2012; 26(4):487-493.

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HIV Prevention in High-Risk Women in South Africa: Condom Use and the Need for Change.
van Loggerenberg F, Dieter AA, Sobieszczyk ME, Werner L, Grobler A, Koleka Mlisana for the CAPRISA 002 Acute Infection Study Team.
PLoS One 2012; 7(2):e30669.

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Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in South Africa.
Loveday M, Wallengren K, Voce A, Margot B, Reddy T, Master I, Brust J, Chaiyachati K, Padayatchi N.
International Journal of Tuberculosis and Lung Disease 2012; 16(2):209-215.

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Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial.
Coovadia HC, Brown ER, Glenn Fowler M, Chipato T, Moodley D, Manji K, Musoke P, Stranix-Chibanda L, Chetty V, Fawzi W, Nakabiito C, Msweli L, Kisenge R, Guay L, Mwatha A, Lynn DJ, Eshleman SH, Richardson P, George K, Andrew PRN, Mofenson LM, Zwerski S, Maldonado Y, for the HPTN 046 protocol team
Lancet 2012; 379(9812):221-8.

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Genital Tract Inflammation During Early HIV-1 Infection Predicts Higher Plasma Viral Load Set Point in Women.
Roberts L, Passmore J-A S, Mlisana K, Williamson C, Little F, Bebell LM, Walzl G, Abrahams M-R, Woodman Z, Abdool Karim Q, Abdool Karim SS.
Journal of Infectious Diseases 2012; 205(2): 194-203.

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Gender-sensitive reporting in medical research.
Heidari S, Abdool Karim Q, Auerbach JD, Buitendijk SE, Cahn P Curno MJ, Hankins C, Katabira E, Kippax S, Marlink R, Marsh J, Marusic A, Nass HM, Montaner J, Pollitzer E, Ruiz-Cantero MT, Sherr L, Sow PS, Squires K, Wainberg MA.
Journal of the International AIDS Society 2012; 15(1):11. doi:10.1186/1758-2652-15-11.

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An AIDS-Free Generation?
Abdool Karim SS
Science 2012; 337: 133.

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Second-line antiretroviral therapy in a workplace and community-based treatment programme in South Africa: Determinants of virological outcome.
Johnston V, Fielding K, Charalambous S, Mampho M, Churchyard G, Phillips A, Grant AD.
PLoS One 2012; 7(5):e36997.

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Organ Donation, Discrimination After Death, Anti-Vaccination Sentiments, and Tuberculosis Management
Coggon J, Madden B, Cockburn T, Stewart C, Singh JA, Bhan A, Upshur RE, Richards B.
Journal of Bioethical Inquiry 2012; 9(2):125-133.

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Women with drug resistant tuberculosis are at increased risk for extensively drug resistant tuberculosis (XDR TB) in KwaZulu Natal, South Africa: A retrospective hospital based study
O'Donnell MR, Zelnick J, Werner L, Master I, Loveday M, Horsburgh RC, Padayatchi N http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310667/

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