Scientific Publications

HIV incidence and associated risk factors in adolescent girls and young women in South Africa: A population-based cohort study
Lewis L, Kharsany ABM, Humphries H, Maughan-Brown B, Beckett S, Govender K, Cawood C, Khanyile D, George G
PLoS One 2022; 17(12): e0279289

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Impact of COVID-19 public health responses on income, food security and health services among key and vulnerable women in South Africa
Humphries H, Lewis L, Lamontagne E, Choonara S, Dikgale K, Yakusik A, Massawe D, Mkhize N, Mzungu F, Abdool Karim Q
African Journal of AIDS Research 2022; 21(4):317-329

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Building on Pasteur's legacy: producing vaccines in Africa
Abdool Karim SS, Sikazwe I
Lancet 2023; 400(10369):2164-2166

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The impact of enteral feeding and therapeutic monitoring of rifampicin with dose-escalation in critically ill patients with tuberculosis
Perumal R, Naidoo K, Naidoo A, Letsoalo MP, Esmail A, Joubert I, Denti P, Wiesner L, Padayatchi N, Maartens G, Dheda K
International Journal of Infectious Diseases 2022; 126:174-180

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Pharmacogenomics of drug transporters for antiretroviral long-acting pre-exposure prophylaxis for HIV
Zondo NM, Sobia P, Sivro A, Ngcapu S, Ramsuran V, Archary D
Frontiers in Genetics 2022; 13:940661

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Culture filtrate supplementation can be used to improve Mycobacterium tuberculosis culture positivity for spinal tuberculosis diagnosis
Beltran CGG, Venter R, Mann TN, Davis JH, Kana BD, Walzl G
Frontiers in Cellular and Infection Microbiology 2022 25;12:1065893

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Impact of Motivational Enhanced Adherence Counseling and Point-of-Care Viral Load Monitoring on Viral Load Outcome in Women on Life-Long ART: A Randomized Pilot Study
Mutambanengwe-Jacob MT, Maponga CC, Amico KR, Ngara B, Yende-Zuma N, Chawana TD, Nematadzira T, Gumbo JF, Goverayi T, Matibe P, Malunda BV, Aizire J, Taha TE, Fowler MG, Stranix-Chibanda L
AIDS Research and Treatment 2022; 2022:4887202

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Curbing antimicrobial resistance in post-COVID Africa: Challenges, actions and recommendations
Shomuyiwa DO, Lucero-Prisno DE 3rd, Manirambona E, Suleman MH, Rayan RA, Huang J, Zaw TN, Babatunde Y, Denkyira SA, Musa SS
Health science reports 2022 8;5(5):e771

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Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size
Rasmussen TA, Ahuja SK, Kuwanda L, Vjecha MJ, Hudson F, Lal L, Rhodes A, Chang J, Palmer S, Auberson-Munderi P, Mugerwa H, Wood R, Badal-Faesen S, Pillay S, Mngqibisa R, LaRosa A, Hildago J, Petoumenos K, Chiu C, Lutaakome J, Kitonsa J, Kabaswaga E, Pala P, Ganoza C, Fisher K, Chang C, Lewin SR, Wright EJ
Clin Infect Dis. 2022; 75(10):1781-1791

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The Impact of Over-The-Counter Lactic Acid Containing Vaginal Gels on the Integrity and Inflammatory State of the Vaginal Epithelium in vitro
Tyssen D, Hearps AC, Guntur K, Masson L, Cook S, Moulton SE, Ravel J, Bradshaw CS, Ayehunie S, Tachedjian G
Frontiers in Reproductive Health 2022; 4:915948

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Assessment of Antibiotic Resistance and Efflux Pump Gene Expression in Neisseria Gonorrhoeae Isolates from South Africa by Quantitative Real-Time PCR and Regression Analysis
Mitchev N, Singh R, Ramsuran V, Ismail A, Allam M, Kwenda S, Mnyameni F, Garrett N, Swe Swe-Han K, Niehaus AJ, Mlisana KP
International Journal of Microbiology 2022; 2022:7318325

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Ethically acceptable consent approaches to adolescent research in South Africa
Loveday M, Goga A, Dhai A, Labuschaigne M, Roussouw T, Burgess T, Strode A, Wallace M, Blockman M, Daniels B, Spooner E, Bekker LG
Southern African Journal of HIV Medicine 2022 ; 23(1):1385

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Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa
Samsunder N, de Vos M, Ngcapu S, Giandhari J, Lewis L, Kharsany AB, Carwood C, de Olveira T, Abdool Karim Q, Abdool Karim SS, Naidoo K, Escadafal C, Sivro A
Journal of Infectious Diseases 2022; 226(8):1412-1417

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Women for science and science for women: gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention
Abdool Karim Q, Archary D, Barré-Sinoussi F, Broliden K, Cabrera C, Chiodi F, Fidler SJ, Gengiah TN, Herrera C, Kharsany A, Liebenberg LJ, Mahomed S, Menu E, Moog C, Scarlatti G, Seddiki N, Sivro A, Cavarelli M; on behalf of FEMIN and CAPRISA
Frontiers in Immunology 2022. doi: 10.3389/fimmu.2022.1055042

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Coronavirus Host Genomics Study: South Africa (COVIGen-SA)
May AK, Seymour H, Etheredge H, Maher H, Nunes MC, Madhi SA, Sokhela SM, Venter WDF, Martinson N, Nabeemeeah F, Cohen C, Moyes J, Walaza S, Tempia S, Kleynhans J, von Gottberg A, Nel J, Dawood H, Variava E, Tollman S, Kahn K, Herbst K, Wong EB, Tiemessen CT, van Blydenstein A, Murray L, Venter M, Fabian J, Ramsay M
Global Health, Epidemiology and Genomics 2022; 2022:7405349

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Maternal and infant renal safety following tenofovir disoproxil fumarate exposure during pregnancy in a randomized control trial
Baltrusaitis K, Makanani B, Tierney C, Fowler MG, Moodley D, Theron G, Nyakudya LH, Tomu M, Fairlie L, George K, Heckman B, Knowles K, Browning R, Siberry GK, Taha TE, Stranix-Chibanda L; PROMISE P1084s Study Team
BMC Infectious Diseases 2022 20;22(1):634

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Editorial: Epigenetics of infectious diseases
Kulkarni S, Arumugam T, Chuturgoon A, An P, Ramsuran V.
Frontiers in Immunology 2022;13:1054151

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High-Throughput B Cell Epitope Determination by Next-Generation Sequencing
Walker LM, Shiakolas AR, Venkat R, Liu ZA, Wall S, Raju N, Pilewski KA, Setliff I, Murji AA, Gillespie R, Makoah NA, Kanekiyo M, Connors M, Morris L, Georgiev IS
Frontiers in Immunology 2022;13:855772

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Impact of Antiretroviral Regimen on Pregnancy and Infant Outcomes in Women With HIV/ HBV Coinfection
Kiweewa FM, Tierney C, Butler K, Peters MG, Vhembo T, Moodley D, Govender V, Mohtashemi N, Ship H, Musoke P, Dula D, George K, Chakhtoura N, Fowler MG, Currier JS, Bhattacharya D
JAIDS 2022;91(1):79-84

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The ethics of exclusion: why pregnant and lactating women must be front and centre of HIV research
Singh JA, Moodley D, Little M, Luna F, Littler K, Kumarasamy N
Journal of the International AIDS Society 2022; 25(Suppl 2):e25926

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Global disparities in SARS-CoV-2 genomic surveillance
Brito AF, Semenova E, Dudas G, Hassler GW, Kalinich CC, Kraemer MUG, Ho J, Tegally H, Githinji G, Agoti CN, Matkin LE, Whittaker C, ......., de Oliveira T, et al.
Nature Communications 2022 16;13(1):7003.

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HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway
Krause R, Snyman J, Shi-Hsia H, Muema D, Karim F, Ganga Y, Ngoepe A, Zungu Y, Gazy I, Bernstein M, Khan K, Mazibuko M, Mthabela N, Ramjit D; COMMIT-KZN Team, Limbo O, Jardine J, Sok D, Wilson IA, Hanekom W, Sigal A, Kløverpris H, Ndung'u T, Leslie A
Elife 2022 27;11:e79924. doi: 10.7554/eLife.79924. PMID: 36300787.

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A multinational Delphi consensus to end the COVID-19 public health threat
Lazarus JV, Romero D, Kopka CJ, Abdool Karim SS, Abu-Raddad LJ, Almeida G, Baptista-Leite R, Barocas JA, Barreto ML, Bar-Yam Y, Bassat Q, Batista C, Bazilian M, Chiou ST, Del Rio C, et al.
Nature. 2022;611(7935):332-345. doi: 10.1038/s41586-022-05398-2.

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Antibody class-switching as a strategy to improve HIV-1 neutralization
Scheepers C, Richardson SI, Moyo-Gwete T, Moore PL
Trends in Molecular Medicine 2022; 28(11):979-988

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Adherence measured using electronic dose monitoring is associated with emergent antiretroviral resistance and poor outcomes in patients co-infected with HIV/AIDS and multidrug-resistant tuberculosis
Bateman M, Wolf A, Chimukangara B, Brust JCM, Lessells R, Amico R, Boodhram R, Singh N, Orrell C, Friedland G, Naidoo K, Padayatchi N, O'Donnell MR
Clinical Infectious Diseases 2022; 75(9):1489-1496. doi: 10.1093/cid/ciac232

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Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice
Peters RPH, Garrett N, Chandiwana N, Kularatne R, Brink AJ, Cohen K, Gill K, Chidarikire T, Wattrus C, Nel JS, Moosa MYS, Bekker LG
Southern African Journal of HIV Medicine 2022; 23(1):1450. doi: 10.4102/sajhivmed.v23i1.1450

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Considerations for choosing soluble immune markers to determine safety of novel vaginal products
Happel AU, Sivro A, Liebenberg LJ, Passmore JA, Mitchell C
Frontiers in Reproductive Health 2022; 4:899277. doi: 10.3389/frph.2022.899277

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Antiretroviral therapy adherence patterns, virological suppression, and emergence of drug resistance: A nested case-control study from Uganda and South Africa
Tyagi A, Tong Y, Rabideau DJ, Reynolds Z, De Oliveira T, Lessells R, Amanyire G, Orrell C, Asiimwe S, Chimukangara B, Giandhari J, Pillay S, Haberer JE, Siedner MJ; META Study Investigators
Antiviral Therapy 2022; 27(5):13596535221114822.

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Analysis of the HIV Vaccine Trials Network 702 Phase 2b–3 HIV-1 Vaccine Trial in South Africa Assessing RV144 Antibody and T-Cell Correlates of HIV-1 Acquisition Risk
Moodie Z, Dintwe O, Sawant S, Grove D, Huang Y, Janes H, Heptinstall J, Laher Omar F, Cohen K, De Rosa SC, Zhang L, Yates NL, Sarzotti-Kelsoe M, Seaton KE, Laher F, Bekker LG, Malahleha M, Innes C, Kassim S, Naicker N, et al.
Journal of Infectious Diseases 2022; 226(2):246-257. doi: 10.1093/infdis/jiac260

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Trends in Cases, Hospitalization and Mortality Related to the Omicron BA.4/BA.5 Sub-Variants in South Africa
Jassat W, Abdool Karim SS, Ozougwu L, Welch R, Mudara C, Masha M, Rousseau P, Wolmarans M, Selikow A, Govender N, Walaza S, von Gottberg A, Wolter N, Terrence Pisa P, Sanne I, Govender S, Blumberg L, Cohen C, Groome MJ; DATCOV author group
Clin Infect Dis. 2022:ciac921. doi: 10.1093/cid/ciac921

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The impact of enteral feeding and therapeutic monitoring of rifampicin with dose-escalation in critically ill patients with tuberculosis
Perumal R, Naidoo K, Naidoo A, Letsoalo MP, Esmail A, Joubert I, Denti P, Wiesner L, Padayatchi N, Maartens G, Dheda K
International Journal of Infectious Diseases 2022.S1201-9712(22)00626-9. doi: 10.1016/j.ijid.2022.11.033

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The Changing Paradigm of Drug-Resistant Tuberculosis Treatment: Successes, Pitfalls, and Future Perspectives
Dookie N*, Ngema SL*, Perumal R, Naicker N, Padayatchi N, Naidoo K
Clinical Microbiology Reviews 2022:e0018019. doi: 10.1128/cmr.00180-19

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Diagnostic accuracy of the Alere Afinion AS100 point-of-care assay to screen for non-communicable diseases amongst people living with HIV
Bodley N, Dorward J, Naidoo J, Letsoalo M, Ramsaroop K, Sayed F, Sookrajh Y, Drain PK, Garrett N
JAIDS 2022. doi: 10.1097/QAI.0000000000003098

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Efficacy and Action of the Dapivirine Vaginal Ring as Understood by Women Participating in an Open Label Extension Study
Naidoo K, Montgomery ET, Katz AW, Garcia M, Reddy K, Soto-Torres L, Naidoo S, Mansoor L
AIDS Behavior 2022. doi: 10.1007/s10461-022-03745-y. Epub ahead of print. https://pubmed.ncbi.nlm.nih.gov/35672549/

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Depression onset and its association with community HIV prevalence: a geospatial and panel analyses of nationally representative South African data, 2015-2017
Asare K, Tomita A, Garrett N, Slotow R, Burns JK, Tanser F, Cuadros DF
Journal of Affective Disorders Reports. 2022; 10 (2022):100433

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Using joint models to study the association between CD4 count and the risk of death in TB/HIV data
Mchunu NN, Mwambi HG, Rizopoulos D, Reddy T, Yende-Zuma N
BMC Medical Research Methodology. 2022 ;22(1):295. doi: 10.1186/s12874-022-01775-7

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The Lancet Commission on lessons for the future from the COVID-19 pandemic.
Sachs JD, Abdool Karim SS, Aknin L, Allen J, Brosbøl K, Colombo F, Barron GC, Espinosa MF, Gaspar V, Gaviria A, Haines A, Hotez PJ, Koundouri P, Bascuñán FL, Lee JK, Pate MA, Ramos G, Reddy KS, Serageldin I, Thwaites J, Vike-Freiberga V, Wang C, Were MK, Xue L, Bahadur C, Bottazzi ME, Bullen C, Laryea-Adjei G, Amor YB, Karadag O, Lafortune G, Torres E, Barredo L, Bartels JGE, Joshi N, Hellard M, Huynh UK, Khandelwal S, Lazarus JV, Michie S
Lancet 2022; 400(10359):1224-1280. doi: 10.1016/S0140-6736(22)01585-9

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Augmenting glycosylation-directed folding pathways enhances the fidelity of HIV Env immunogen production in plants
Margolin E, Allen JD, Verbeek M, Chapman R, Meyers A, van Diepen M, Ximba P, Motlou T, Moore PL, Woodward J, Strasser R, Crispin M, Williamson AL, Rybicki EP
Biotechnology and Bioengineering 2022;119(10):2919-37

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Development of a synthetic nanoparticle vaccine presenting the HIV-1 envelope glycoprotein
Ximba P, Chapman R, Meyers A, Margolin E, van Diepen MT, Sander AF, Woodward J, Moore PL, Williamson AL, Rybicki EP
Nanotechnology 2022;33(48). doi: 10.1088/1361-6528/ac842c

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Validation and application of a quantitative LC-MS/MS assay for the analysis of first-line anti-tuberculosis drugs, rifabutin and their metabolites in human breast milk
Zuma P, Joubert A, van der Merwe M, Norman J, Waitt C, Court R, Loveday M, Castel S, Wiesner L
Journal of Chromatography B. 2022; 1211:123489

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Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil
Giovanetti M, Slavov SN, Fonseca V, Wilkinson E, Tegally H, Patané JSL, Viala VL, San EJ, Rodrigues ES, Santos EV, .........., de Oliveira T, Holmes EC, Haddad R, Sampaio SC, Elias MC, Kashima S, Junior de Alcantara LC, Covas DT
Nature Microbiology 2022;7(9):1490-1500

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Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data
Hughes SM, Levy CN, Katz R, Lokken EM, Anahtar MN, Hall MB, Bradley F, Castle PE, Cortez V, Doncel GF, Fichorova R, Fidel PL Jr, Fowke KR, Francis SC, Ghosh M, Hwang LY, Jais M, Jespers V, Joag V, Kaul R, Kyongo J, Lahey T, Li H, Makinde J, McKinnon LR, Moscicki AB, Novak RM, Patel MV, Sriprasert I, Thurman AR, Yegorov S, Mugo NR, Roxby AC, Micks E, Hladik F; Consortium for Assessing Immunity Across the Menstrual Cycle
BMC Medicine 2022 5;20(1):353. doi: 10.1186/s12916-022-02532-9

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Baseline host determinants of robust human HIV-1 vaccine-induced immune responses: A meta-analysis of 26 vaccine regimens
Huang Y, Zhang Y, Seaton KE, De Rosa S, Heptinstall J, Carpp LN, Randhawa AK, McKinnon LR, McLaren P, Viegas E, Gray GE, Churchyard G, Buchbinder SP, Edupuganti S, Bekker LG, Keefer MC, Hosseinipour MC, Goepfert PA, Cohen KW, Williamson BD, McElrath MJ, Tomaras GD, Thakar J, Kobie JJ; NIAID HIV Vaccine Trials Network (HVTN) 073/South African AIDS Vaccine Initiative (SAAVI) 102, HVTN 086/SAAVI 103, HVTN 094, HVTN 097, HVTN 098, HVTN 100, HVTN 105, HVTN 111, and HVTN 205 Protocol Leadership Teams
EBioMedicine 2022; 84:104271

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PrEP uptake and delivery setting preferences among clients visiting six healthcare facilities in Eswatini
Inghels M, Kim HY, Tanser F, Hettema A, McMahon SA, Oldenburg CE, Matse S, Kohler S, Geldsetzer P, Bärnighausen T
AIDS and Behavior 2022;26(10):3345-3355

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Building a Resilient Scientific Network for COVID-19 and Beyond
Babady NE, Burckhardt RM, Krammer F, Moore PL, Enquist LW
mBio 2022; 20:e0222322.

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The Effect Of Contraception On Genital Cytokines In Women Randomized To Copper Intrauterine Device, Intramuscular Depot Medroxyprogesterone Acetate Or Levonorgestrel Implant
Tanko RF, Bunjun R, Dabee S, Jaumdally SZ, Onono M, Nair G, Palanee-Phillips T, Harryparsad R, Happel AU, Gamieldien H, Qumbelo Y, Sinkala M, Scoville CW, Heller K, Baeten JM, Bosinger SE, Burgener A, Heffron R, Jaspan HB, Passmore JS
Journal of Infectious Diseases 2022; 226(5):907-919.

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Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms
Moyo-Gwete T, Scheepers C, Makhado Z, Kgagudi P, Mzindle NB, Ziki R, Madzorera S, Manamela NP, Ayres F, Lambson BE, Richardson SI, Morris L, Moore PL
Scientific Reports 2022; 12(1):16473

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Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition
Gilbert PB*, Huang Y*, deCamp AC, Karuna S, Zhang Y, Magaret CA, Giorgi EE, Korber B, Edlefsen PT, .........., Garrett N, Sanchez J, Gay C, Makhema J, Williamson C, Mullins JI, Hural J, Cohen MS, Corey L, Montefiori DC, Morris L
Nature Medicine 2022; 28(9):1924-1932

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Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants
Moyo-Gwete T, Madzivhandila M, Mkhize NN, Kgagudi P, Ayres F, Lambson BE, Manamela NP, Richardson SI, Makhado Z, van der Mescht MA, de Beer Z, de Villiers TR, Burgers WA, Ntusi NAB, Rossouw T, Ueckermann V, Boswell MT, Moore PL
Journal of Virology 2022; 96(15):e0055822.

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Detection of differentially culturable tubercle bacteria in sputum from drug-resistant tuberculosis patients
Gordhan BG, Sewcharran A, Letsoalo M, Chinappa T, Yende-Zuma N, Padayatchi N, Naidoo K, Kana BD
Frontiers in Cellular and Infection Microbiology 2022 ;12:949370. doi: 10.3389/fcimb.2022.949370

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Pyrazinamide resistance in rifampicin discordant tuberculosis
Mvelase NR, Singh R, Swe Swe-Han K, Mlisana KP
PLoS One 2022;17(9):e0274688

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Impact of point-of-care testing on the management of sexually transmitted infections in South Africa: Evidence from the HVTN702 HIV vaccine trial
Asare K, Andine T, Naicker N, Dorward J, Singh N, Spooner E, Andriesen J, Osman F, Ngcapu S, Vandormael A, Mindel A, Abdool Karim SS, Bekker LG, Gray G, Corey L, Tomita A, Garrett N
Clinical Infectious Diseases 2022:ciac824. doi: 10.1093/cid/ciac824

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Vaginal microbial shifts are unaffected by oral pre-exposure prophylaxis in South African women
Mazibuko-Motau N*, Sobia P*, Xu J, Elsherbini JA, San JE, Lewis L, Mtshali A, Mzobe G, Ntuli L, Abdool Karim SS, Mansoor LE, Abdool Karim Q, Kwon DS, Archary D, Ngcapu S
Scientific Reports 2022;12(1):16187. doi: 10.1038/s41598-022-20486-z

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Can a conditional financial incentive (CFI) reduce socio-demographic inequalities in home-based HIV testing uptake? A secondary analysis of the HITS clinical trial intervention in rural South Africa
Inghels M, Kim HY, Mathenjwa T, Shahmanesh M, Seeley J, Wyke S, McGrath N, Sartorius B, Yapa HM, Dobra A, Bärnighausen T, Tanser F
Social Science & Medicine 2022; 311:115305

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Case-fatality and sequelae following acute bacterial meningitis in South Africa, 2016 through 2020
Meiring S, Cohen C, de Gouveia L, Plessis MD, Quan V, Kleynhans J, Menezes C, Reubenson G, Dawood H, Nchabeleng M, Said M, Mvelase N, Mahabeer P, Chomba R, Lekalakala R, Nana T, Chibabhai V, Black M, Gottberg AV; for GERMS-SA
Journal of Infectious Diseases 2022; 122:1056-1066.

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Predicting the Risk of Human Immunodeficiency Virus Type 1 (HIV-1) Acquisition in Rural South Africa Using Geospatial Data
Roberts DA, Cuadros D, Vandormael A, Gareta D, Barnabas RV, Herbst K, Tanser F, Akullian A
Clinical Infectious Diseases 2022; 75(7):1224-1231

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Analysis of the HIV Vaccine Trials Network 702 Phase 2b–3 HIV-1 Vaccine Trial in South Africa Assessing RV144 Antibody and T-Cell Correlates of HIV-1 Acquisition Risk
Moodie Z, Dintwe O, Sawant S, Grove D, Huang Y, Janes H, Heptinstall J, Laher Omar F, Cohen K, De Rosa SC, Zhang L, Yates NL, Sarzotti-Kelsoe M, Seaton KE, Laher F, Bekker LG, Malahleha M, Innes C, Kassim S, Naicker N, Govender V, Sebe M, Singh N, Kotze P, Lazarus E, Nchabeleng M, Ward AM, Brumskine W, Dubula T, Randhawa AK, Grunenberg N, Hural J, Kee JJ, Benkeser D, Jin Y, Carpp LN, Allen M, D'Souza P, Tartaglia J, DiazGranados CA, Koutsoukos M, Gilbert PB, Kublin JG, Corey L, Andersen-Nissen E, Gray GE, Tomaras GD, McElrath MJ
Journal of Infectious Diseases 2022; 226(2):246-257

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HIV prevention for the next decade: Appropriate, person-centred, prioritised, effective, combination prevention
Godfrey-Faussett P, Frescura L, Abdool Karim Q, Clayton M, Ghys PD; (on behalf of the 2025 prevention targets working group)
PLoS Medine 2022;19(9):e1004102

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Brief Report: Quantifiable Plasma Tenofovir Among South African Women Using Daily Oral Pre-exposure Prophylaxis During the ECHO Trial
Beesham I, Mansoor LE, Joseph Davey DL, Palanee-Phillips T, Smit J, Ahmed K, Selepe P, Louw C, Singata-Madliki M, Kotze P, Heffron R, Parikh UM, Wiesner L, Rees H, Baeten JM, Beksinska M
JAIDS 2022; 91(1):26-30

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Breakthrough SARS-CoV-2 infections during periods of delta and omicron predominance, South Africa
Goga A, Bekker LG, Garrett N, Reddy T, Yende-Zuma N, Fairall L, Moultrie H, Takalani A, Trivella V, Faesen M, Bailey V, Seocharan I, Gray GE; Sisonke study team
Lancet 2022; 400(10348):269-271

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Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin-resistant tuberculosis
Court R, Gausi K, Mkhize B, Wiesner L, Waitt C, McIlleron H, Maartens G, Denti P, Loveday M
British Journal of Clinical Pharmacology 2022; 88(8):3548-3558

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Genital inflammatory status and the innate immune response to contraceptive initiation
Radzey N, Harryparsad R, Meyer B, Chen PL, Gao X, Morrison C, Taku O, Williamson AL, Mehou-Loko C, d'Hellencourt FL, Buck G, Smit J, Strauss J, Nanda K, Ahmed K, Beksinska M, Serrano M, Bailey V, Masson L, Deese J
American Journal of Reproductive Immunology 2022; 88(2):e13542

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Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Delgado-Diaz DJ, Jesaveluk B, Hayward JA, Tyssen D, Alisoltani A, Potgieter M, Bell L, Ross E, Iranzadeh A, Allali I, Dabee S, Barnabas S, Gamieldien H, Blackburn JM, Mulder N, Smith SB, Edwards VL, Burgener AD, Bekker LG, Ravel J, Passmore JS, Masson L, Hearps AC, Tachedjian G
Microbiome 2022;10(1):141

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Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus
Happi C, Adetifa I, Mbala P, Njouom R, Nakoune E, Happi A, Ndodo N, Ayansola O, Mboowa G, Bedford T, Neher RA, Roemer C, Hodcroft E, Tegally H, O'Toole Á, Rambaut A, Pybus O, Kraemer MUG, Wilkinson E, Isidro J, Borges V, Pinto M, Gomes JP, Freitas L, Resende PC, Lee RTC, Maurer-Stroh S, Baxter C, Lessells R, Ogwell AE, Kebede Y, Tessema SK, de Oliveira T
PLOS Biology 2022; 20(8):e3001769

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Neurodevelopmental Outcomes of HIV and Anti-retroviral Drug Perinatally Exposed Uninfected Children Aged 3-6 years
Fowler MG, Hanrahan C, Yende-Zuma N, Stranix-Chibanda L, Chipato T, Maliwichi L, Gadama L, Aizire J, Dadabahi S, Chinula L, Wambuzi-Owang L, Owor M, Violoari A, Nyati M, Hanley S, Govender V, Brummel S, Taha T
AIDS 2022; 36(11):1533-1543

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Post-COVID-19 condition 3 months after hospitalisation with SARS-CoV-2 in South Africa: a prospective cohort study
Dryden M, Mudara C, Vika C, Blumberg L, Mayet N, Cohen C, Tempia S, Parker A, Nel J, Perumal R, Groome MJ, Conradie F, Ndjeka N, Sigfrid L, Merson L, Jassat W
Lancet Global Health 2022;10(9):e1247-e1256

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Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies
Scheepers C, Kgagudi P, Mzindle N, Gray ES, Moyo-Gwete T, Lambson BE, Oosthuysen B, Mabvakure B, Garrett NJ, Abdool Karim SS, Morris L, Moore PL
PLoS Pathogens 2022;18(9):e1010450

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Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV)
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HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies.
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Prospective study of oral pre-exposure prophylaxis initiation and adherence among young women in KwaZulu-Natal, South Africa
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Ring-ing in the Future: Participant and Male Partner Perspectives Regarding Future Use of the Dapivirine Vaginal Ring for HIV Prevention
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Mandatory COVID-19 Vaccination: Lessons from Tuberculosis and HIV
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Age-Restriction of a Validated Risk Scoring Tool Better Predicts HIV Acquisition in South African Women: CAPRISA 004
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Prospective multicentre head-to-head validation of host blood transcriptomic biomarkers for pulmonary tuberculosis by real-time PCR
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Nature 2022. doi: 10.1038/s41586-022-04830-x.

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Phylogeographic Assessment Reveals Geographic Sources of HIV-1 Dissemination Among Men Who Have Sex With Men in Kenya
duva GM, Otieno F, Kimani J, McKinnon LR, Cholette F, Sandstrom P, Graham SM, Price MA, Smith AD, Bailey RC, Hassan AS, Esbjörnsson J, Sanders EJ
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Evaluation of a transcriptomic signature of tuberculosis risk in combination with an interferon gamma release assay: A diagnostic test accuracy study
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High Asymptomatic Carriage with the Omicron Variant in South Africa
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Does the Ring Work? Perceptions and Understanding of the Efficacy of a Dapivirine Vaginal Ring for HIV Prevention Amongst Women in a Placebo-Controlled Trial
Etima J, Katz AWK, Duby Z, Garcia M, Palanee-Phillips T, Reddy K, Mathebula F, Zimba C, Mansoor LE, Singh D, Manengamambo E, Naidoo S, Soto-Torres L, Montgomery ET; MTN-020/ASPIRE, MTN 025/HOPE, MTN-032 Study teams
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Sisonke phase 3B open-label study: Lessons learnt for national and global vaccination scale-up during epidemics
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South African Medical Journal 2022;112(5b):375-383

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CD4+ T-cell count at antiretroviral therapy initiation in the "treat all" era in rural South Africa: an interrupted time series analysis
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Replacement of the Gamma by the Delta variant in Brazil: Impact of lineage displacement on the ongoing pandemic
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AMA Network Open 2022; 5(4):e228640

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Nature Microbiology 2022;7(3):365-366

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Clinical predictors of pulmonary tuberculosis among South African adults with HIV
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Socioeconomic Burdens of the COVID-19 Pandemic on LMIC Populations with Increased HIV Vulnerabilities
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mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Garcia-Beltran WF, St Denis KJ, Hoelzemer A, Lam EC, Nitido AD, Sheehan ML, Berrios C, Ofoman O, Chang CC, Hauser BM, Feldman J, Roederer AL, Gregory DJ, Poznansky MC, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB
Cell 2022; 185(3):457-466

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Xpert MTB/XDR for rapid detection of drug-resistant tuberculosis beyond rifampicin
Mvelase NR, Mlisana KP
Lancet Infectious Diseases 2022; 22(2):156-157

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Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data
Schaefer R, Amparo da Costa Leite PH, Silva R, Abdool Karim Q, Akolo C, Cáceres CF, Dourado I, Green K, Hettema A, Hoornenborg E, Jana S, Kerschberger B, Mahler H, Matse S, McManus H, Molina JM, Reza-Paul S, Azwa I, Shahmanesh M, Taylor D, Vega-Ramirez H, Veloso VG, Baggaley R, Dalal S
Lancet HIV 2022; 9(4): e242-e253

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Public understanding of science: Communicating in the midst of a pandemic
Abdool Karim SS
Public Understanding of Science. 2022; 31(3):282-287

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Comparative immunogenicity and effectiveness of mRNA-1273, BNT162b2 and Ad26.COV2.S COVID-19 vaccines
Naranbhai V, Garcia-Beltran WF, Chang CC, Mairena CB, Thierauf JC, Kirkpatrick G, Onozato ML, Cheng J, St Denis KJ, Lam EC, Kaseke C, Tano-Menka R, Yang D, Pavlovic M, Yang W, Kui A, Miller TE, Astudillo MG, Cahill JE, Dighe AS, Gregory DJ, Poznansky MC, Gaiha GD, Balazs AB, Iafrate AJ
Journal of Infectious Diseases 2022 225(7):1141-1150

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Clinical severity of COVID-19 in patients admitted to hospital during the omicron wave in South Africa: a retrospective observational study
Jassat W, Abdool Karim SS, Mudara C, Welch R, Ozougwu L, Groome MJ, Govender N, von Gottberg A, Wolter N, Wolmarans M, Rousseau P; DATCOV author group, Blumberg L, Cohen C
Lancet Global Health 2022

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Omicron - Decoupling Infection from Severe Disease
Moore PL, Baden LR
New England Journal of Medicine 2022; 386:1361-1362

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Advancing HIV prevention using tenofovir-based pre-exposure prophylaxis
Abdool Karim SS, Baxter C, Abdool Karim Q
Antiviral Therapy 2022; 27(2):13596535211067589

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Endothelial cells promote productive HIV infection of resting CD4+ T cells by an integrin-mediated cell adhesion-dependent mechanism
Card CM, Abrenica B, McKinnon LR, Ball TB, Su RC
AIDS Research and Human Retroviruses 2022; 38(2):111-126

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T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals
Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Zhao Z, St Denis KJ, Lam EC, Carrington M, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GD
Cell 2022; 185(6):1041-1051

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Addressing Vaccine Inequity - Covid-19 Vaccines as a Global Public Good
Hunter DJ, Abdool Karim SS, Baden LR, Farrar JJ, Hamel MB, Longo DL, Morrissey S, Rubin EJ
New England Journal of Medicine 2022; 386(12):1176-1179

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Effectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study
Bekker LG, Garrett N, Goga A, Fairall L, Reddy T, Yende-Zuma N, Kassanjee R, Collie S, Sanne I, Boulle A, Seocharan I
The Lancet. 2022; 399(10330):1141-53

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COVID-19 vaccine wastage in the midst of vaccine inequity: causes, types and practical steps
Lazarus JV, Abdool Karim SS, van Selm L, Doran J, Batista C, Ben Amor Y, Hellard M, Kim B, Kopka CJ, Yadav P
BMJ Global Health 2022; 7(4):e009010

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Impact of SARS-CoV-2 variants of concern on Covid-19 epidemic in South Africa
Abdool Karim SS, Baxter C
Transactions of the Royal Society of South Africa 2022; 77(1): 101–104.

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Safety and pharmacokinetics of monoclonal antibodies VRC07-523LS and PGT121 administered subcutaneously for HIV prevention
Mahomed S, Garrett N, Capparelli EV, Osman F, Harkoo I, Yende-Zuma N, Gengiah TN, Archary D, Samsunder N, Baxter C, Mkhize NN, Modise T, Carlton K, McDermott A, Moore PL, Abdool Karim Q, Barouch DH, Fast PE, Mascola JR, Ledgerwood JE, Morris L, Abdool Karim SS
Journal of Infectious Diseases 2022

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Quantifying rates of HIV-1 flow between risk groups and geographic locations in Kenya: A country-wide phylogenetic study
Nduva GM, Otieno F, Kimani J, Wahome E, McKinnon LR, Cholette F, Majiwa M, Masika M, Mutua G, Anzala O, Graham SM, Gelmon L, Price MA, Smith AD, Bailey RC, Baele G, Lemey P, Hassan AS, Sanders EJ, Esbjörnsson J
Virus Evolution 2022 March; 8(1):veac016

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Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern
Kitchin D, Richardson SI, van der Mescht MA, Motlou T, Mzindle N, Moyo-Gwete T, Makhado Z, Ayres F, Manamela NP, Spencer H, Lambson B, Oosthuysen B, Kaldine H, du Pisanie M, Mennen M, Skelem S, Williams N, Ntusi NAB, Burgers WA, Gray GG, Bekker LG, Boswell MT, Rossouw TM, Ueckermann V, Moore PL
Cell Reports Medicine 2022; 3(3):100535

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The effect of host factors on discriminatory performance of a transcriptomic signature of tuberculosis risk
Mulenga H, Fiore-Gartland A, Mendelsohn SC, Penn-Nicholson A, Mbandi SK, Borate B, Musvosvi M, Tameris M, Walzl G, Naidoo K, Churchyard G, Scriba TJ, Hatherill M; CORTIS Study Team
EBioMedicine. 2022; 77:103886

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HPV and the Risk of HIV Acquisition in Women
Zayats R, Murooka TT, McKinnon LR
Frontiers in Cellular and Infection Microbiology 2022; 12:814948

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Single-chain variable fragments of broadly neutralizing antibodies prevent HIV cell-cell transmission
van Dorsten RT, Reh L, Trkola A, Morris L, Moore PL
Journal of Virology 2022; 96(4):e0193421

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TB testing in HIV-positive patients prior to antiretroviral treatment
Spooner E, Reddy S, Ntoyanto S, Sakadavan Y, Reddy T, Mahomed S, Mlisana K, Dlamini M, Daniels B, Luthuli N, Ngomane N, Kiepiela P, Coutsoudis A
International Journal of Tuberculosis and Lung Disease 2022; 26(3):224-231

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Xpert MTB/XDR for rapid detection of drug-resistant tuberculosis beyond rifampicin
Mvelase NR, Mlisana KP
Lancet Infectious Diseases 2022; 22(2):156-157.

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Selection of HIV Envelope strains for standardized assessments of vaccine-elicited antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies
Mielke D, Stanfield-Oakley S, Borate B, Fisher LH, Faircloth K, Tuyishime M, Greene K, Gao H, Williamson C, Morris L, Ochsenbauer C, Tomaras G, Haynes BF, Montefiori D, Pollara J, deCamp AC, Ferrari G.
Journal of Virology 2022; 96(2):e0164321.

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SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape
Cele S, Karim F, Lustig G, San JE, Hermanus T, Tegally H, Snyman J, Moyo-Gwete T, Wilkinson E, Bernstein M, Khan K, Hwa SH, Tilles SW, Singh L, Giandhari J, Mthabela N, Mazibuko M, Ganga Y, Gosnell BI, Abdool Karim SS, Hanekom W, Van Voorhis WC, Ndung'u T; COMMIT-KZN Team, Lessells RJ, Moore PL, Moosa MS, de Oliveira T, Sigal A
Cell Host Microbe. 2022; 30(2):154-162.

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HLA-A*03 and response to immune checkpoint blockade in cancer: an epidemiological biomarker study
Naranbhai V, Viard M, Dean M, Groha S, Braun DA, Labaki C, Shukla SA, Yuki Y, Shah P, Chin K, Wind-Rotolo M, Mu XJ, Robbins PB, Gusev A, Choueiri TK, Gulley JL, Carrington M
Lancet Oncol. 2022;23(1):172-184.

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Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study
Naranbhai V, Pernat CA, Gavralidis A, St Denis KJ, Lam EC, Spring LM, Isakoff SJ, Farmer JR, Zubiri L, Hobbs GS, How J, Brunner AM, Fathi AT, Peterson JL, Sakhi M, Hambelton G, Denault EN, Mortensen LJ, Perriello LA, Bruno MN, Bertaux BY, Lawless AR, Jackson MA, Niehoff E, Barabell C, Nambu CN, Nakajima E, Reinicke T, Bowes C, Berrios-Mairena CJ, Ofoman O, Kirkpatrick GE, Thierauf JC, Reynolds K, Willers H, Beltran WG, Dighe AS, Saff R, Blumenthal K, Sullivan RJ, Chen YB, Kim A, Bardia A, Balazs AB, Iafrate AJ, Gainor JF
J Clin Oncol. 2022; 40(1):12-23.

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Recurrent subclinical tuberculosis among ART accessing participants: Incidence, clinical course, and outcomes
Naidoo K, Moodley MC, Hassan-Moosa R, Dookie N, Yende-Zuma N, Perumal R, Dawood H, Mvelase NR, Mathema B, Abdool Karim SS
Clinical Infectious Diseases 2022.

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Tuberculosis Elimination in the Era of COVID-19: A Moving Target
Dookie N, Padayatchi N, Naidoo K.
Clinical Infectious Diseases 2022; 74(3):509-510

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Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization
Cele S, Jackson L, Khoury DS, Khan K, Moyo-Gwete T, Tegally H, San JE, Cromer D, Scheepers C, Amoako DG, Karim F, Bernstein M, Lustig G, Archary D, Smith M, Ganga Y, Jule Z, Reedoy K, Hwa SH, Giandhari J, Blackburn JM, Gosnell BI, Abdool Karim SS, Hanekom W; NGS-SA; COMMIT-KZN Team, von Gottberg A, Bhiman JN, Lessells RJ, Moosa MS, Davenport MP, de Oliveira T, Moore PL, Sigal A
Nature 2022;602(7898):654-656.

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Multi-drug-resistant tuberculosis clusters in Mpumalanga province, South Africa, 2013-2016: A spatial analysis
Mashamba MA, Tanser F, Afagbedzi S, Beke A
Tropical Medicine & International Health 2022;27(2):185-191.

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Pre-infection plasma cytokines and chemokines as predictors of HIV disease progression
Ngcobo S, Molatlhegi RP, Osman F, Ngcapu S, Samsunder N, Garrett NJ, Abdool Karim SS, Abdool Karim Q, McKinnon LR, Sivro A
Scientific Reports 2022;12(1):2437

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High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens
Mitchev N, Singh R, Ramsuran V, Ismail A, Allam M, Kwenda S, Mnyameni F, Garrett N, Swe-Han KS, Niehaus AJ, Mlisana KP
International Journal of Microbiology 2022 18;2022:9094328.

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Early and unintended pregnancies threaten triple dividend
Choonara S, Govender K, Mpofu D, Kapira A, Humphries H
Lancet Child Adolescent Health. 2022;6(2):79-80.

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In Silico Characterisation of Putative Prophages in Lactobacillaceae Used in Probiotics for Vaginal Health
Happel AU, Kullin BR, Gamieldien H, Jaspan HB, Varsani A, Martin D, Passmore JA, Froissart R
Microorganisms 2022;10(2):214

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Enhancing oral PrEP uptake among adolescent girls and young women in Africa
Heck C J, Abdool Karim Q
International AIDS Society 2022; 25(1): e25876.

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Implants for HIV prevention in young women: Provider perceptions and lessons learned from contraceptive implant provision
Humphries H, Upfold M, Mahlase G, Mdladla M, Gengiah T, Abdool Karim Q
PLoS One 2022 13;17(1):e0262043.

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CAPRISA 018: a phase I/II clinical trial study protocol to assess the safety, acceptability, tolerability and pharmacokinetics of a sustained-release tenofovir alafenamide subdermal implant for HIV prevention in women
Gengiah TN, Abdool Karim Q, Harkoo I, Mansoor L, Zuma NY, Radebe P, Samsunder N, Baxter C, Maharaj B, Baum MM, Moss JA, Pozzetto B, Hankins C, Abdool Karim SS
BMJ Open 2022; 12(1):e052880.

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Neutralization breadth of SARS-CoV-2 viral variants following primary series and booster SARS-CoV-2 vaccines in patients with cancer
Naranbhai V, St Denis KJ, Lam EC, Ofoman O, Garcia-Beltran WF, Mairena CB, Bhan AK, Gainor JF, Balazs AB, Iafrate AJ; CANVAX team
Cancer Cell 2022 5;40(1):103–108.e2.

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Prevalent HPV infection increases the risk of HIV acquisition in African women: advancing the argument for HPV immunization
Liu G, Mugo NR, Brown ER, Mgodi NM, Chirenje ZM, Marrazzo JM, Winer RL, Mansoor L, Palanee-Phillips T, Siva SS, Naidoo L, Jeenarain N, Gaffoor Z, Nair GL, Selepe P, Nakabiito C, Mkhize B, Mirembe BG, Taljaard M, Panchia R, Baeten JM, Balkus JE, Hladik F, Celum CL, Barnabas RV
AIDS 2022; 36(2):257-265.

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Mortality in HIV and tuberculosis patients following implementation of integrated HIV-TB treatment: Results from an open-label cluster-randomized trial
Naidoo K, Gengiah S, Yende-Zuma N, Mlobeli R, Ngozo J, Memela N, Padayatchi N, Barker P, Nunn A, Abdool Karim SS.
eClinicalMedicine 2022;44:101298.

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Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma
Cele S, Gazy I, Jackson L, Hwa SH, Tegally H, Lustig G, Giandhari J, Pillay S, Wilkinson E, Naidoo Y, Karim F, Ganga Y, Khan K, Bernstein M, Balazs AB, Gosnell BI, Hanekom W, Moosa MS; NGS-SA; COMMIT-KZN Team, Lessells RJ, de Oliveira T, Sigal A.
Nature 2021; 593(7857):142-146

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SIV susceptibility, immunology and microbiome in the female genital tract of adolescent versus adult pigtail macaques
Berard AR, Miller C, Araínga M, Broedlow CA, Noël-Romas L, Schifanella L, Hensley-McBain T, Roederer A, Driscoll C, Coronado E, Manuzak J, McKinnon LR, Villinger FJ, Hope TJ, Burgener AD, Klatt NR.
AIDS Res Hum Retroviruses 2021;37(7):510-522.

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Modeling the temporal dynamics of cervicovaginal microbiota identifies targets that may promote reproductive health
Munoz A, Hayward MR, Bloom SM, Rocafort M, Ngcapu S, Mafunda NA, Xu J, Xulu N, Dong M, Dong KL, Ismail N, Ndung'u T, Ghebermichael MS, Kwon DS.
Microbiome 2021; 9(1):163.

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COVID-19 in Africa: Catalyzing change for sustainable development
Abdool Karim SS, Kelemu S, Baxter C.
PLoS Medicine 2021; 18(11):e1003869.

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Should global financing be the main priority for pandemic preparedness?
IJsselmuiden C, Ntoumi F, Lavery JV, Montoya J, Abdool Karim SS, Kaiser K.
Lancet 2021; 398(10298):388.

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mRNA vaccines offer hope for HIV
Morris L.
Nature Medicine 2021; 27(12):2082-2084.

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Impact of SARS-CoV-2 variants of concern on Covid-19 epidemic in South Africa
Abdool Karim SS, Baxter C.
Transactions of the Royal Society of South Africa 2021

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Recent Advances and New Challenges in Cisgender Women's Gynecologic and Obstetric Health in the Context of HIV
Deese J, Heffron R, Jaspan H, Masson L, Smit JA, Sibeko S.
Clinical Obstetrics and Gynecology 2021; 64(3):475-490.

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Build on HIV investments for future pandemic preparedness
Collins C, Isbell MT, Ratevosian J, Beyrer C, Abdool Karim Q, Maleche A, Sohn AH.
BMJ Global Health 2021; 6(12):e007980.

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"This is not my body": Therapeutic experiences and post-treatment health of people with rifampicin-resistant tuberculosis
Loveday M, Hlangu S, Larkan LM, Cox H, Daniels J, Mohr-Holland E, Furin J.
PLoS One 2021; 16(10):e0251482.

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Performance of TaqMan probes for the detection of sexually transmitted infections in South African women
Mitchev N, Singh R, Garrett N, Ramsuran V, Niehaus AJ, Mlisana KP.
African Journal of Laboratory Medicine 2021; 10(1):1124

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PRINCIPLE Trial Collaborative Group. Inclusion and diversity in the PRINCIPLE trial
Patel MG, Dorward J, Yu LM, Hobbs FR, Butler CC.
Lancet 2021; 397(10291):2251-2252.

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Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study.
Mendelsohn SC, Fiore-Gartland A, Penn-Nicholson A, Mulenga H, Mbandi SK, Borate B, Hadley K, Hikuam C, Musvosvi M, Bilek N, Erasmus M, Jaxa L, Raphela R, Nombida O, Kaskar M, Sumner T, White RG, Innes C, Brumskine W, Hiemstra A, Malherbe ST, Hassan-Moosa R, Tameris M, Walzl G, Naidoo K, Churchyard G, Scriba TJ, Hatherill M.
Lancet Global Health 2021; 9(6):e841-e853.

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HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral treatment in KwaZulu-Natal Province, South Africa
Chimukangara B, Lessells RJ, Sartorius B, Gounder L, Manyana S, Pillay M, Singh L, Giandhari J, Govender K, Samuel R, Msomi N, Naidoo K, de Oliveira T, Moodley P, Parboosing R.
Journal of Global Antimicrobial Resistance 2021 14:S2213-7165(21)00249-6.

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Simplifying TREAtment and Monitoring for HIV (STREAM HIV): protocol for a randomised controlled trial of point-of-care urine tenofovir and viral load testing to improve HIV outcomes
Bardon AR, Dorward J, Sookrajh Y, Sayed F, Quame-Amaglo J, Pillay C, Feutz E, Ngobese H, Simoni JM, Sharma M, Cressey TR, Gandhi M, Lessells R, Moodley P, Naicker N, Naidoo K, Thomas K, Celum C, Abdool Karim SS, Garrett N, Drain PK.
BMJ Open 2021;11(10):e050116.

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A cluster-randomized controlled trial to improve the quality of integrated HIV-tuberculosis services in primary healthcare clinics in South Africa
Gengiah S, Barker PM, Yende-Zuma N, Mbatha M, Naidoo S, Taylor M, Loveday M, Mhlongo M, Jackson C, Nunn AJ, Padayatchi N, Abdool Karim SS, Naidoo K.
Journal of the International AIDS Society 2021;24(9):e25803.

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Immunological correlates of the HIV-1 replication-competent reservoir size
Ismail SD, Riou C, Joseph SB, Archin NM, Margolis DM, Perelson AS, Cassidy T, Abrahams MR, Moeser M, Council OD, McKinnon LR, Osman F, Abdool Karim Q, Abdool Karim SS, Swanstrom R, Williamson C, Garrett NJ, Burgers WA.
Clinical Infectious Diseases 2021; 73(8):1528-1531.

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ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection
Mielke D, Bandawe G, Zheng J, Jones J, Abrahams MR, Bekker V, Ochsenbauer C, Garrett N, Abdool Karim S, Moore PL, Morris L, Montefiori D, Anthony C, Ferrari G, Williamson C.
PLoS Pathogens 2021; 17(11):e1010046.

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Transient association between semen exposure and biomarkers of genital inflammation in South African women at risk of HIV infection.
Jewanraj J, Ngcapu S, Osman F, Ramsuran V, Fish M, Mtshali A, Singh R, Mansoor LE, Abdool Karim SS, Abdool Karim Q, Passmore J-A S, Liebenberg LP.
Journal of the International AIDS Society 2021; 24:e25766.

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