Scientific Publications

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.
Baeten JM, Palanee‑Phillips T, Brown ER, Schwartz K, Soto‑Torres LE, Govender V, Mgodi NM, Matovu Kiweewa F, Nair G, Mhlanga F, Siva S, Bekker L-G, Jeenarain N, Gaffoor Z, Martinson F, Makanani B, et al.
New England Journal of Medicine 2016; 375(22):2121-2132.

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Metabolic syndrome after HIV acquisition in South African women.
Sobieszczyk ME, Werner L, Mlisana K, Naicker N, Feinstein A, Gray CM, Masson L, Passmore J-AS, Williamson C, Abdool Karim Q, Abdool Karim SS, Garrett NG.
AIDS 2016; 73(4):438-445.

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Elucidating the role of clofazimine for the treatment of tuberculosis.
O'Donnell MR, Padayatchi N, Metcalfe JZ.
International Journal of Tuberculosis and Lung Disease 2016; 20(12): 52-57.

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Approaches to the induction of HIV broadly neutralizing antibodies.
Moore PL, Williamson C.
Current Opinion in HIV and AIDS 2016; 11(6): 569-575.

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Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention.
Fowler MG, Qin M, Fiscus SA, Currier JS, Flynn PM, Chipato T, McIntyre J, Gnanashanmugam D, Siberry GK, Coletti AS, Taha TE, Klingman KL, Martinson FE, Owor M, Violari A, Moodley D, Theron GB, Bhosale R, Bobat R, Chi BH, Strehlau R, Mlay P, Loftis AJ, Browning R, Fenton T, Purdue L, Basar M, Shapiro DE, Mofenson LM.
New England Journal of Medicine 2016; 375(18):1726-37.

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Mental health of and substance use by adolescents.
Abdool Karim Q.
South African Medical Journal 2016; 106(6):547.

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Psychosocial wellbeing of patients with multidrug resistant tuberculosis voluntarily confined to long-term hospitalisation in Nigeria
Oladimeji O, Ushie BA, Udoh EE, Oladimeji KE, Ige OM, Obasanya O, Lekharu D, Atilola O, Lawson L, Eltayeb O, Gidado M, Tsoka-Gwegweni JM, Ihekweazu CA, Chasela CS. Psychosocial wellbeing of patients with multidrug resistant tuberculosis voluntarily confined to long-term hospitalisation in Nigeria
BMJ Global Health 2016; 1(3):e000006

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Outcomes of on-site antiretroviral therapy provision in a South African correctional facility.
Telisinghe L, Hippner P, Churchyard GJ, Gresak G, Grant AD, Charalambous S, Fielding KL.
International Journal of STD and AIDS 2016; 27(13):1153-61.

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Structure of an N276-dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole adjacent to the CD4 Binding Site.
Wibmer CK, Gorman J, Anthony CS, Mkhize NN, Druz A, York T, Schmidt SD, Labuschagne P, Louder MK, Bailer RT, Abdool Karim SS, Mascola JR, Williamson C, Moore PL, Kwong PD, Morris L.
Journal of Virology 2016; 90(22):10220-35.

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Antibiotic Stewardship for Drug resistant Tuberculosis.
Padayatchi N, Mahomed S, Loveday M, Naidoo K.
Expert Opinion On Pharmacotherapy 2016; 17(15):1981-3.

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New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency
Doria-Rose NA, Bhiman JN, Roark RS, Schramm CS, Gorman J, Chuang GY, Pancera M, Cale EM, Ernandes MJ, Louder MK, Asokan M, Bailer RT, Druz A, Frascilla IR, Garrett NJ, Jarosinski M, Lynch RM, McKee K, O’Dell S, Pegu A, Schmidt SD, Staupe RP, Sutton MS, Wang K, Wibmer CK, Haynes BF, Abdool-Karim SS, Shapiro L, Kwong PD, Moore PL, Morris L, Mascola JR.
Journal of Virology 2016; 90(1):76-91.

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Young women's life experiences and perceptions of sexual and reproductive health in rural KwaZulu-Natal South Africa.
Waxman AM, Humphries H, Frohlich J, Dlamini S, Ntombela F.
Culture, Health and Sexuality 2016;18(10):1122-36.

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Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool Karim SS, Boyd SD, Melillo B, Smith AB, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF.
EBioMedicine 2016;12:196-207.

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Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast AJ, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg CB, Walker BD, Ndung'u T, Jooste P, Moore PL, Morris L, Goulder P.
Science Translational Medicine 2016; 8(358): 358ra125. doi: 10.1126/scitranslmed.aag1048.

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Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.
Rademeyer C, Korber B, Seaman MS, Giorgi EE, Thebus R, Robles A, Sheward DJ, Wagh K, Garrity J, Carey BR, Gao H, Greene KM, Tang H, Bandawe GP, Marais JC, Diphoko TE, P Hraber P, Tumba N, Moore PL, Gray GE, Kublin J, McElrath MJ, Vermeulen M, Middelkoop K, Bekker L-G, Hoelscher M, Maboko L, Makhema J, Robb ML, Abdool Karim S, Abdool Karim Q, Kim JH, Hahn BH, Gao F, Swanstrom R, Morris L, Montefiori DC, Williamson C.
PLoS Pathogens 12(7):e1005742.

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Measuring ventilation and modelling M. tuberculosis transmission in indoor congregate settings, rural KwaZulu-Natal.
Taylor JG, Yates TA, Mthethwa M, Tanser F, Abubakar I, Altamirano H.
International Journal of Tuberculosis and Lung Disease 2016; 20(9):1155-61.

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Genetic polymorphisms of CCL2 associated with susceptibility to latent tuberculous infection in Thailand.
Nonghanphithak D, Reechaipichitkul W, Namwat W, Lulitanond V, Naranbhai V, Faksri K.
International Journal of Tuberculosis and Lung Disease 2016; 20(9):1242-8.

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CD8+ T cell breadth and ex vivo virus inhibition capacity distinguish between viremic controllers with and without protective HLA class I alleles.
Koofhethile CK, Ndhlovu ZM, Thobakgale-Tshabalala C, Prado JG, Ismail N, Mncube Z, Mkhize I, Van der Stok M, Yende-Zuma N, Walker BD, Goulder PJ, Ndung'u T.
Journal of Virology 2016; 90(15):6818-31.

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Repeat Use of Post-exposure Prophylaxis for HIV Among Nairobi-Based Female Sex Workers Following Sexual Exposure.
Izulla P, McKinnon LR, Munyao J, Ireri N, Nagelkerke N, Gakii G, Gelmon L, Nangami M, Kaul R, Kimani J.
AIDS Behaviour 2016; 20(7):1549-55.

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Strengthening HIV surveillance: measurements to track the epidemic in real time.
Buthelezi UE, Davidson CL, Kharsany AB.
African Journal of AIDS Research 2016; 15(2):89-98.

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An empiric HIV risk scoring tool to predict HIV-1 acquisition in African women
Balkus JE, Brown E, Palanee T, Nair G, Gafoor Z, Zhang J, Richardson BA, Chirenje ZM, Marrazzo JM, Baeten JM
Journal of Acquired Immune Deficiency Syndromes 2016; 72(3):333-343

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Social Context of Adherence in an Open-Label 1 % Tenofovir Gel Trial: Gender Dynamics and Disclosure in KwaZulu-Natal, South Africa.
MacQueen KM, Dlamini S, Perry B, Okumu E, Sortijas S, Singh C, Pillay D, Majors A, Jerome S, Watson S, Abdool Karim SS, Abdool Karim Q, Mansoor LE.
AIDS and Behavior 2016; 20(11):2682-2691.

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Factors driving the HIV epidemic in southern Africa.
McKinnon LR, Abdool Karim Q.
Current HIV/AIDS Reports 2016;13(3):158-69.

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Diagnostic accuracy of the point-of-care xpert HIV-1 viral load assay in a South African HIV Clinic.
Garrett NJ, Drain PK, Werner L, Samsunder N, Abdool Karim SS.
JAIDS 2016; 72(2):e45-48.

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Combination HIV prevention options for young women in Africa.
Baxter C, Abdool Karim SS.
African Journal of AIDS Research 2016; 15(2):109-121.

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Implementation and Operational Research: Clinical Impact of the Xpert MTB/RIF Assay in Patients With Multidrug-Resistant Tuberculosis.
Padayatchi N, Naidu N, Yende-Zuma N, O’Donnell MR, Naidoo K, Augustine S, Zumla A, Loveday M.
JAIDS 2016; 73(1):e1-7. doi: 10.1097/QAI.0000000000001110

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Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance
Desjardins CA, Cohen KA, Munsamy V, Abeel T, Maharaj K, Walker BJ, Shea TP, Almeida DV, Manson AL, Salazar A, Padayatchi N, O'Donnell MR, Mlisana KP, Wortman J, Birren BW, Grosset J, Earl AM, Pym AS.
Nature Genetics 2016;48(5):544-51.

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Using PMTCT to raise overall health and development.
Coovadia H, Moodley D.
The Lancet HIV 2016; 3(5): e192–e193.

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Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel.
Archary D, Seaton KE, Passmore JS, Werner L, Deal A, Dunphy LI, Arnold KB, Yates NL, Lauffenburger DA, Bergin P, LiebenbergLI, Samsunder N, Mureithi MW, Altfeld M, Garrett N, Abdool Karim Q, Abdool Karim SS, Morris L, and Tomaras GD.
Mucosal Immunology 2016; 9(3): 821-833.

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Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women.
Mkhize N, Durgiah R, Archary D, Garrett N, Moore P, Abdool Karim, Q, Abdool Karim SS, Passmore JS, Tomaras G, Ashley V, Yates N, Morris, L.
AIDS 2016; 30(7):1005-1014.

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Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection.
Wagh K, Bhattacharya T, Williamson C, Robles A, Bayne M, Garrity J, Rist M, Rademeyer C, Yoon H, Lapedes A, Gao H, Greene K, Louder MK, Kong R, Abdool Karim S, Burton DR, Barouch DH, Nussenzweig MC, Mascola JR, Morris L, Montefiori DC, Korber B, Seaman MS.
PLOS Pathogens 2016;12(3):e1005520.

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“Bitten By Shyness”: Menstrual Hygiene Management, Sanitation, and the Quest for Privacy in South Africa.
Scorgie F, Foster J, Stadler J, Phiri T, Hoppenjans L, Rees H, Muller N.
Medical Anthropology: Cross Cultural Studies in Health and Illness 2016; 35(2)161-176.

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Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial.
Hosseinipour MC, Bisson GP, Miyahara S, Sun X, Moses A, Riviere C, Kirui FK, Badal-Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger PD, Lama JR, Mohapi L, Alave J, Mave V, Veloso VG, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A.
Lancet 2016; 387(10024):1198-209.

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When treatment is more challenging than the disease: A qualitative study of MDR-TB patient retention.
Shringarpure KS, Isaakidis P, Sagili KD, Baxi RK, Das M, Daftary A.
PLoS ONE 2016; 11(3): e0150849.

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Which new health technologies do we need to achieve an end to HIV/AIDS?
Gray GE, Laher F, Doherty T, Abdool Karim SS, Hammer S, Mascola J, Beyrer C, Corey L.
PLoS Biology 2016; 14(3): e1002372.

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Genital inflammation, immune activation and risk of sexual HIV acquisition.
Passmore J, Jaspan HB, Masson L.
Current opinion in HIV and AIDS 2016; 11(2):156-62.

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Microbial translocation and microbiome dysbiosis in HIV-associated immune activation.
Zevin AS, McKinnon L, Burgener A, Klatt NR.
Curr Opin HIV AIDS 2016; 11(2):182-190.

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Identification of preferential CD4+ T cell targets for HIV infection in the cervix.
Joag VR, McKinnon L, Liu J, Kidane ST, Yudin MH, Nyanga B, Kimwaki S, Besel KE, Obila JO, Huibner S, Oyugi JO, Arthos J, Anzala O, Kimani J, Ostrowski MA, the Toronto HIV Research Group, Kaul R.
Mucosal Immunology 2016; 9(1):1-12.

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Oral and injectable contraceptive use and HIV acquisition risk among women in four African countries: a secondary analysis of data from a microbicide trial
Balkus JE, Brown ER, Hillier SL, Coletti A, Ramjee G, Mgodi N, Makanani B, Reid C, Martinson F, Soto-Torres L, Abdool Karim SS, Chirenje ZM
Contraception 2016; 93(1):25-31

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Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.
Kløverpris HN, Kazer SW, Mjösberg J, Mabuka JM, Wellmann A, Ndhlovu Z, Yadon MC, Nhamoyebonde S, Muenchhoff M, Simoni Y, Andersson F, Kuhn W, Garrett N, Burgers WA, Kamya P, Pretorius K, Dong K, Moodley A, Newell EW, Kasprowicz V, Abdool Karim SS, Goulder P, Shalek AK, Walker BD, Ndung'u T, Leslie A.
Immunity 2016; 44(2):391-405.

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Do gifts increase consent to home-based HIV testing? A difference-in-differences study in rural KwaZulu-Natal, South Africa.
McGovern ME, Herbst K, Tanser F, Mutevedzi T, Canning D, Gareta D, Pillay D, and Bärnighausen T.
International Journal of Epidemiology 2016; 45(6):2100-9.

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The Role of Host Genetics (and Genomics) in Tuberculosis.
Naranbhai V.
Microbiology spectrum 2016; 4(5). doi: 10.1128/microbiolspec.TBTB2-0011-2016.

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HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.
Vince N, Li H, Ramsuran V, Naranbhai V, Duh FM, Fairfax BP, Saleh B, Knight JC, Anderson SK, Carrington M.
The American Journal of Human Genetics 2016; 99(6):1353-1358.

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HIV-1 glycan density drives the persistence of the mannose patch within an infected individual.
Coss KP, Vasiljevic S, Pritchard LK, Krumm SA, Glaze M, Madzorera S, Moore PL, Crispin M, Doores KJ.
Journal of Virology 2016; 90(24):11132-44.

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Early Resumption of Sex following Voluntary Medical Male Circumcision amongst School-Going Males.
George G, Govender K, Beckett S, Montague C, Frohlich J.
PLoS One 2016; 11(12):e0168091.

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Pulmonary effects of timing of antiretroviral therapy initiation.
Dawood H.
Lancet Respiratory Medicine 2016; 4(12):929-930.

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Dual-Reporter Mycobacteriophages (ϕ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum.
Jain P, Weinrick BC, Kalivoda EJ, Yang H, Munsamy V, Vilcheze C, Weisbrod TR, Larsen MH, O’Donnell MR, Pym A, Jacobs WR.
MBio 2016; 7(5):e01023-16.

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Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens.
Shaffer JS, Moore PL, Kardar M, and Chakraborty AK.
Proceedings of the National Academy of Sciences 2016; 113(45): e7039-e7048.

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Provider perspectives on drug-resistant tuberculosis and human immunodeficiency virus care in South Africa: a qualitative case study.
Daftary A, Padayatchi N.
International Journal of Tuberculosis and Lung Disease 2016; 20(11): 1483-88.

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Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA.
Science 2016; 354(6309): 197-202.

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Association of polymorphisms in the regulatory region of the cyclophilin A gene (PPIA) with gene expression and HIV/AIDS disease progression.
Madlala P, Singh R, An P, Werner L, Mlisana K, Abdool Karim SS, Winkler CA, Ndung'u T.
JAIDS 2016; 72(5):465-473.

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Assessing Adherence to Antiretroviral Therapy in a Rural Paediatric Cohort in KwaZulu-Natal, South Africa.
Smith C, Gengiah TN, Yende-Zuma N, Upfold M, Naidoo K.
AIDS and behavior 2016; 20(11):2729-38.

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Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection.
Masson L, Arnold KB, Little F, Mlisana K, Lewis DA, Mkhize N, Gamieldien H, Ngcapu S, Johnson L, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS.
Sexually Transmitted Infections 2016; 92(3):186-193.

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Re-inventing adherence: toward a patient-centered model of care for drug-resistant tuberculosis and HIV
O’Donnell MR, Daftary A, Frick M, Hirsch-Moverman Y, Amico KR, Senthilingam M, Wolf A, Metcalfe JZ, Isaakidis P, Davis JL, Zelnick RJ, Brust JCM, Naidu N, Garretson M, Bangsberg DR, Padayatchi N, Friedland G.
International Journal of Tuberculosis and Lung Diseases 2016; 20(4):430-434.

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Tuberculosis treatment outcomes among peri-urban children receiving doorstep tuberculosis care
Jeena L, Naidoo K.
The International Journal of Tuberculosis and Lung Disease 2016; 20(2): 235-239.

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Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women.
Naranbhai V, de Assis Rosa D, Werner L, Moodley R, Hong H, Kharsany A, Mlisana K, Sibeko S, Garrett N, Chopera D, Carr WH, Abdool Karim Q, Hill AV, Abdool Karim SS, Altfeld M, Gray CM, Ndung'u T.
BMC Infectious Diseases 2016; 16(1):27. doi: 10.1186/s12879-016-1361-1.

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High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa.
Ebrahim, S, Mndende, XK, Kharsany, ABM, Mbulawa, ZZA, Naranbhai, V, Frohlich, J, Werner, L, Samsunder, N, Abdool Karim, Q, Williamson, AL.
PLOS One 2016; 11(1): e0146603.

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Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.
Arnold KB, Burgener A, Birse K, Romas L, Dunphy LJ, Shahabi K, Abou M, Westmacott GR, McCorrister S, Kwatampora J, Nyanga B, Kimani J, Masson L, Liebenberg LJ, Abdool Karim SS, Passmore J-AS, Lauffenburger DA, Kaul R, McKinnon LR.
Mucosal Immunology 2016; 9(1):194-205.

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Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor Binding Site.
Bradley T, Fera D, Bhiman J, Eslamizar L, Lu X, Anasti K, Zhang R, Sutherland LL, Scearce RM, Bowman CM, Stolarchuk C, Lloyd KE, Robert Parks R, Martelli A, Foulger A, Nie X, Abdool Karim SS, Barnett S, Kelsoe G, Kepler TB, S. Alam M, Montefiori DC, Moody MA, Liao H-X, Morris L, Santra S, Harrison SC and Haynes BF.
Cell Reports 2016;14(1):43-54.

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Oral and injectable contraceptive use and HIV acquisition risk among 1 women in 4 African 2 countries: a secondary analysis of data from a microbicide trial.
Balkus JE, Brown ER, Hillier SL, Coletti A, Ramjee G, Mgodi N, Makanani B, Reid C, Martinson F, Soto-Torres L, Abdool Karim SS, Chirenje ZM.
Contraception 2016; 93(1):25-31.

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Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.
Gorman J, Soto C, Yang MM, Davenport TM, Guttman M, Bailer RT, Chambers M, Chuang GY, DeKosky BJ, Doria-Rose NA, Druz A, Ernandes MJ, Georgiev IS, Jarosinski MC, Joyce MG1, Lemmin TM, Leung S, Louder MK, McDaniel JR, Narpala S, Pancera M, Stuckey J, Wu X, Yang Y, Zhang B, Zhou T, Program NC, Mullikin JC, Baxa U, Georgiou G, McDermott AB, Bonsignori M, Haynes BF, Moore PL, Morris L, Lee KK, Shapiro L, Mascola JR, Kwong PD.
Nature Structural and Molecular Biology 2016; 23(1):81-90.

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