CAPRISA Studies

Below is a list of CAPRISA studies. The protocols for each study can be accessed by clicking on the title of the study. Researchers wanting to access data from the completed CAPRISA studies are requested to complete a data request form. The form can be accessed here

STUDY	ABBREVIATED TITLE	TITLE	PRINCIPAL INVESTIGATOR/S	TYPE OF STUDY
ONGOING
CAP 097	TAF Implant	To assess post removal implant insertion site healing, implant acceptability and pre-exposure prophylaxis (PrEP) product user preferences in previous CAPRISA 018 trial participants.	Dr Tanuja N. Gengiah	Cohort study
CAP 002	Acute Infection Study	Viral set point and clinical disease progression: the role of immunological, genetic and viral factors over the course of disease and during antiretroviral therapy	Prof Salim Abdool Karim	Observational
CAP 018	TAF Implant	A phase I/II trial to assess the safety, acceptability and pharmacokinetics of a sustained-release tenofovir alafenamide sub-dermal implant for HIV prevention in women	Prof Salim Abdool Karim	RCT
CAP 020	InDEX	Effectiveness of indivualized XDR-TB treatment study; a strategy to improve treatment outcomes in patients with XDR TB	Dr Nesri Padayatchi / Prof Kogie Naidoo	RCT
CAP 086	PRAXIS	PRospective study of Adherence in M/XDR-TB Implementation Science	Dr Nesri Padayatchi / Dr Max O'Donnell	Cohort Study
CAP 090	MIST Study	Mucosal Injury from Sexual Trauma: Understanding the Interaction Of Biology And Behaviour Of South African Adolescents	Dr Jo-Ann Passmore/ Heather Jaspan	Cohort Study
CAP 091	STREAM 2 -HIV	Simplifying Treatment and Monitoring for HIV (STREAM HIV): Point-of-Care Urine Tenofovir Adherence and Viral Load Testing to Improve HIV Outcomes in South Africa	Dr Nigel Garrett /Dr Paul Drain	RCT
CAP 093	INSIGHT study	INSTI’s for the management of HIV-associated TB: A phase 2b study to evaluate the efficacy, safety and pharmacokinetics of a combination of Bictegravir, Emtricitabine, and Tenofovir Alafenamide Fumarate for treatment of HIV-1 infection in patients with drug-susceptible tuberculosis on a Rifampicin-based treatment regimen	Dr Anushka Naidoo
CAP 255	POwER	POwER: Point Of care viral load testing to Enhance Re-suppression	Dr Nigel Garrett/ Dr Jiecheni Doward
CAP 257	PHILA	PHILA: Point of care HIV viral Load testing in a community ART programme	Dr Nigel Garrett / Dr Jiecheni Doward
CAP 058	ORCHID	Optimizing dolutegraviR dosing in TB co-infected CHIlDren	Dr Anushka Naidoo / Dr Moherndran Archary

		COMPLETED
CAP 001	START trial	Starting Tuberculosis and Anti-Retroviral Therapy Trial: A Randomized Controlled Trial to Assess the Effect of Integrated Tuberculosis and HIV Care on the Incidence of AIDS-Defining Conditions or Mortality in participants Co-Infected with Tuberculosis and HIV.	Prof Salim Abdool Karim	RCT
CAP 003	SAPIT trial	A Study to compare three existing starting points of ART Initiation in HIV/TB co-infected patients	Prof Salim Abdool Karim	RCT
CAP 004	Tenofovir gel trial	Phase IIb Trial to Assess the Safety and Effectiveness of the Vaginal Microbicide 1% Tenofovir Gel for the Prevention of HIV Infection in Women in South Africa	Prof Salim Abdool Karim / Prof Quarraisha Abdool Karim	RCT
CAP 005	TRuTH study	TB Recurrence upon Treatment with HAART	Prof Kogie Naidoo / Prof Salim Abdool Karim	Cohort Study
CAP 007	RHIVA	Reducing HIV in Adolescents (RHIVA). A proof of concept cluster randomised controlled trial to evaluate the impact of a cash incentivised prevention intervention to reduce HIV infection in high school llearners in rural KwaZulu-Natal, South Africa	Prof Quarraisha Abdool Karim	RCT
CAP 008	Tenofovir gel implementation trial	Open-Label Randomized Controlled Trial to Assess the Implementation Effectiveness and Safety of 1% Tenofovir Gel Provision through Family Planning Services in KwaZulu-Natal, South Africa	Prof Quarraisha Abdool Karim / Prof Salim Abdool Karim / Dr Leila Mansoor	Randomised, Non-inferiority Open-label trial
CAP 009	TOAST	Open Label Randomized Controlled Trial to Assess the Impact of prophylactic exposure to tenofovir gel on the efficacy of subsequent tenofovir-containing antiretroviral therapy on viral suppression	Dr Nivashnee Naicker /Prof Salim Abdool Karim /Dr Anushka Naidoo	RCT
CAP 011	IMPRESS	Improving retreatment success	Dr Nesri Padayatchi	RCT
CAP 012A	Broadly Neutralising Antibody	A Phase ǀ Study to determine the Safety and Pharmacokinetics of the Human monoclonal Antibodies, VRC07-523LS and PGT121 administered subcutaneously to HIV negative Adults in South Africa	Prof Salim Abdool Karim	RCT
CAP 013	SUTHI	Addressing challenges in scaling up TB and HIV Treatment integration in Public Health settings in South Africa	Prof Kogie Naidoo	RCT
CAP 050	Seroincidence study	HIV Incidence Rates in Vulindlela and Durban: A Prevention Preparedness Study (Vulindlela)	Prof Quarraisha Abdool Karim	Cohort Study
CAP 051	Seroincidence study	HIV Incidence Rates in Vulindlela and Durban: A Prevention Preparedness Study(eThekwini)	Prof Quarraisha Abdool Karim	Cohort Study
CAP 054	WiseBag study	A pilot study to assess feasibility of utilizing a prototype Wisebag for enhancing measurement of gel use in CAPRISA 004	Dr Leila Mansoor / Dr Tanuja Gengiah	Pilot
CAP 055	ANC Survey (annual)	Temporal trends in HIV infection in rural KwaZulu-Natal - implications for research and programmatic priority setting	Prof Ayesha Kharsany	Survey
CAP 056	XDR-TB & HIV / PROX	A prospective study of treatment outcomes in extensively drug resistant tuberculosis (XDR Study)	Dr Nesri Padayatchi / Dr Max O'Donnell	Cohort Study
CAP 057	Contraception	Women’s understanding and practices regarding method choice for fertility control and/or disease prevention in KwaZulu-Natal	Dr Cheryl Baxter	Cohort Study
CAP 075	URLPAI	Understanding socio-demographic and behavioral factors that result in patients seeking care with advanced stage HIV/AIDS disease in the context of free public sector access to Antiretroviral Therapy	Prof Kogie Naidoo	Cohort Study
CAP 078	HEPS	Evaluation of HIV-specific Immunological and virological responses of HIV-1 multiply-exposed seronegative individuals	Prof Salim Abdool Karim	Cohort Study
CAP 081	BLIX	A Retrospective Chart Review of Patients with M(X)DR-TB and TB services	Dr Nesri Padayatchi	Chart Review
CAP 083	STI study	Changing the STI care model to reduce genital inflammation and HIV risk in South African women	Dr Nigel Garrett / Prof Anne Rompalo	Cohort Study
CAP 082	PrEP Implementation study	Prospective study of HIV risk factors and prevention choices in young woman in KZN, South Africa	Dr Leila Mansoor	Cohort study
CAP 084	PrEP Implementation study	A demonstration project of daily, oral tenofovir disoproxil fumarate + emtricitabine pre-exposure prophylaxis (PrEP) as part of sexual reproductive health services for young women at high risk of acquiring HIV in KwaZulu-Natal: Informing policy and practice for PrEP scale-up	Prof Quarraisha Abdool Karim	Implementation Programme
CAP 085	CANS	Identifying sources of HIV infection in adolescent girls in rural South Africa	Prof Ayesha Kharsany	Cohort Study
CAP 087	STREAM Study	Point-of-care viral load testing to enable streamlined care and task shifting for chronic HIV care	Dr Nigel Garrett / Dr Paul Drain	RCT
CAP 088	HPP study	HIV incidence rates, socio-behavioural and biological HIV risk factors, HIV transmission rates and acceptability of prep during pregnancy and/or post-natally in KwaZulu-Natal	Dr Daya Moodley	Cohort Study
CAP 104	Case Control (004)	Microbicide Case Control Study to evaluate behavioural patterns of risk and gel use in a phase 2b trial	Dr Kate McQueen / Dr Francois van Loggenberg	Nested case-control study
CAP 106	CAP 106 TFV-SHSR study	CAPRISA 106 Tenofovir Gel Social and Health Systems Research Study	Dr Sarah Dlamini / Dr Kate MacQueen / Dr Kristine Torjesen	Social Science
CAP 251	HIPSS	Point-of-care viral load testing to enable streamlined care and task shifting for chronic HIV care	Prof Ayesha Kharsany	Cohort Study