The use of scientific expertise in government policymaking was crucial during the height of the COVID-19 pandemic. This emerged from a symposium in Durban, attended by some of the world's leading minds in science, for CAPRISA's 20th anniversary. CAPRISA - the Centre for the Aids Programme of Research in South Africa - has been at the forefront of research into HIV/Aids. Epidemiologists reflected on how healthcare and governments had to function symbiotically to end global pandemics.