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Pharmacokinetics and safety of dolutegravir in children receiving rifampicin tuberculosis treatment in South Africa (ORCHID): a prospective cohort study
Naidoo A, Waalewijn H, Naidoo K, Letsoalo M, Cromhout G, Sewnarain L, Mosia NR, Osuala EC, Wiesner L, Wasmann RE, Denti P, Dooley KE, Archary M; ORCHID study team.
Lancet HIV

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Predicted dolutegravir resistance in people living with HIV in South Africa during 2020-35: a modelling study
Loosli T, Han N, Hauser A, Josi J, Ingle SM, van Sighem A, Wittkop L, Vehreschild J, Ceccherini-Silberstein F, Maartens G, Gill MJ, Sabin CA, Johnson LF, Lessells R, Günthard HF, Egger M, Kouyos RD.
Lancet Global Health

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Mobilising national and regional assets and non-state actors for pandemic preparedness
Sun L, Selbie D, Khan AS,Abdool Karim SS, Legido-Quigley H, Ogunsola FT, Eamer G, Matsoso MP, Bausch DG, Fisher D.
Lancet

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High burden of human papillomavirus and premalignant cervical lesions among women starting HIV treatment in KwaZulu-Natal, South Africa
Naicker N, Osman F, Naidoo K, Bodley N, Mbambo N, Madlala S, Mhlongo T, Mbatha N, Maphumulo A, Munatsi P, Radebe P, Liebenberg L, Dorward J, Drain PK, Garrett N.
Sexually Transmitted Infections

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Differences in HIV risk factors between South African adolescents and adult women and their association with sexually transmitted infections
Mkhize P, Mehou-Loko C, Maphumulo N, Radzey N, Abrahams AG, Sibeko S, Harryparsad R, Manhanzva M, Meyer B, Radebe P, Liebenberg LJP, Ngcapu S, Ahmed N, Busakwe F, Mqaba N, Archary D, Sivro A, Samsunder N, Potloane D, Horsnell W, Jordan C, Abdool Karim Q, Bekker LG, Passmore JA, Jaspan H, Humphries H, Masson L.
Sexually Transmitted Infections

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Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium tuberculosis Clinical Isolates
Rajagopalan S, Rourke AK, Asare E, Kohlerschmidt DJ, Das L, Ngema SL, Mulholland CV, Vilchèze C, Mahalingam V, Moodley S, Truebody B, Mackenzie J, Steyn AJC, Perumal R, Berney M, Larsen MH, O'Donnell MR, Escuyer VE, Jacobs WR Jr.
Journal of Infectious Diseases

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Impact of increasing CD4 count threshold eligibility for antiretroviral therapy initiation on advanced HIV disease and tuberculosis prevalence and incidence in South Africa: an interrupted time series analysis
Asare K, Lewis L, van der Molen J, Sookrajh Y, Khubone T, Ngwenya T, Mkhize NS, Lessells RJ, Naidoo K, Sosibo P, Bottomley C, Garrett N, Dorward J.
BMJ Global Health

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Pharmacokinetics and safety of dolutegravir in children receiving rifampicin tuberculosis treatment in South Africa (ORCHID): a prospective cohort study
Anushka Naidoo, PhDa,∙ Hylke Waalewijn, PhDc ∙ Kogieleum Naidoo, PhDa,b ∙ Marothi Letsoalo, MSca ∙ Gabriela Cromhout, MBBSd ∙ Leora Sewnarain, HDEde ∙ Nozibusiso R Mosia, BNURe ∙ Emmanuella C Osuala, MPharma ∙ Prof Lubbe Wiesner, PhDc ∙ Roeland E Wasmann, PhDc ∙ Prof Paolo Denti, PhDc ∙ Prof Kelly E Dooley, MDf,† ∙ Prof Moherndran Archary, PhDe,† on behalf of the ORCHID study team
The Lancet

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Acceptability of an annual tenofovir alafenamide implant for HIV prevention in South African women: findings from the CAPRISA 018 Phase I clinical trial
Tanuja N. Gengiah, Craig J. Heck, Lara Lewis, Leila E. Mansoor, Ishana Harkoo, Nqobile Myeni, Marc M. Baum, John A. Moss, James F. Rooney, Catherine Hankins, Bruno Pozzetto, Salim S. Abdool Karim, Quarraisha Abdool Karim
JIAS

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Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection
Perugino CA, Liu H, Feldman J, Marbourg J, Guy TV, Hui A, Ingram N, Liebaert J, Chaudhary N, Tao W, Jacob-Dolan C, Hauser BM, Mian Z, Nathan A, Zhao Z, Kaseke C, Tano-Menka R, Getz MA, Senjobe F, Berrios C, Ofoman O, Manickas-Hill Z, Wesemann DR, Lemieux JE, Goldberg MB, Nündel K, Moormann A, Marshak-Rothstein A, Larocque RC, Ryan ET, Iafrate JA, Lingwood D, Gaiha G, Charles R, Balazs AB, Pandit A, Naranbhai V, Schmidt AG, Pillai S.
Cell Reports

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Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection.
Perugino CA, Liu H, Feldman J, Marbourg J, Guy TV, Hui A, Ingram N, Liebaert J, Chaudhary N, Tao W, Jacob-Dolan C, Hauser BM, Mian Z, Nathan A, Zhao Z, Kaseke C, Tano-Menka R, Getz MA, Senjobe F, Berrios C, Ofoman O, Manickas-Hill Z, Wesemann DR, Lemieux JE, Goldberg MB, Nündel K, Moormann A, Marshak-Rothstein A, Larocque RC, Ryan ET, Iafrate JA, Lingwood D, Gaiha G, Charles R, Balazs AB, Pandit A, Naranbhai V, Schmidt AG, Pillai S.
Cell Reports

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Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters
Ahmed JI, Krosta SJ, Reimer MN, Cheung W, Mesa C, Lopez C, Chua RJ, Alsattari F, Robinson A, Manguiat K, Jahan N, Abrenica B, Harris A, Cachero K, Fabia R, Walker J, Oo MM, Stein D, Ji H, Su RC, McLaren PJ, McKinnon LR, Ball TB, Wood H, Kim J, Kiazyk SA, Card CM.
Frontiers in Immunology

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Exploring the female genital tract mycobiome in young South African women using metaproteomics
Gangiah TK, Alisoltani A, Potgieter M, Bell L, Ross E, Iranzadeh A, McDonald Z, Allali I, Dabee S, Barnabas S, Blackburn JM, Tabb DL, Bekker LG, Jaspan HB, Passmore JS, Mulder N, Masson L.
Microbiome

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High mortality among patients with tuberculosis accessing primary care facilities: secondary analysis from an open-label cluster-randomised trial
Naidoo K, Yende-Zuma N, Moodley M, Made F, Perumal R, Gengiah S, Ngozo J, Padayatchi N, Nunn A, Abdool Karim SS.
EClinicalMedicine

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Spatial Analysis of HIV Determinants Among Females Aged 15-34 in KwaZulu Natal, South Africa: A Bayesian Spatial Logistic Regression Model
Chireshe E, Chifurira R, Chinhamu K, Batidzirai JM, Kharsany ABM.
International Journal of Environmental Research and Public Health

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Strategies for relapse prevention among people with schizophrenia in KwaZulu-Natal Province, South Africa: Healthcare providers' perspectives
Mlay JP, Naidu T, Ramlall S, Patankar K, Israel K, Esquivel L, Curran L, Mhlungu SS, Zondi M, Lessells R, Tomita A, Manuel JI.
PloS One

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Surveillance for Chlamydia trachomatis variants escaping detection with the Aptima Combo 2 assay in Canada from 2019 to 2021
Roy F, Beirnes J, LeBlanc JJ, Gibbons S, Sivro A, Severini A; Canadian Public Health Laboratory Network (CPHLN) Chlamydia Variant Working Group.
Microbiology Spectrum

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The persistent pool of HIV-1-infected cells is formed episodically during untreated infection
Council OD, Tyers L, Moeser M, Sondgeroth A, Spielvogel E, Richardson BD, Doolabh D, Zhou S, Emery A, Archin NM, Shook-Sa B, Margolis DM, Abdool Karim SS, Kosakovsky Pond S, Garrett N, Abrahams M-R, Joseph SB, Williamson C, Swanstrom R.
Journal of Virology

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Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis
Garcia-Prats AJ, Garcia-Cremades M, Cox V, Kredo T, Dunbar R, Schaaf HS, Seddon JA, Furin J, Achar J, Radke K, Sachs T, Abubakirov A, Ahmed S, Akkerman OW, Al Ani NA, Amanullah F, Ahmad N, Anderson LF, Asfaw M, Bango F, Bauer T, Becerra M, Boeree M, Brinkmann F, Brown R, Brust J, Campbell JR, Carvalho AC, Carvalho I, Cegielski JP, Centis R, Chan ED, Chauhan S, Chiang SS, Chan PC, D'Ambrosio L, Dalcolmo M, Daneilyan N, de Vries G, Draper HR; endTB Study Group; Fairlie L, Francis JR, Franke M, Gegia M, Restrepo CG, Guenther A, Gureva T, Haecker B, Harausz E, Hewison C, Hicks RM, Huerga H, Hughes J, Isaakidis P, Kadri SM, Khan MA, Kotrikadze T, Kuksa L, Lachenal N, Lange C, Lecca L, Lopez-Varela E, Lucena S, Mariandyshev A, Mattoo S, Mendez-Echevarria A, Migliori GB, Mitnick C, Mohr-Holland E, Mulanda W, Murzabakova T, Myrzalieve B, Ndjeka N, Niemann S, Ozere I, Padayatchi N, Parmar M, Parpieva N, Manzur-Ul-Alam M, Rybak N, Sachdeva KS, Salmon K, Santiago-Garcia B, Schaub D, Shah I, Shah S, Shah V, Sharma S, Shim TS, Shin S, Sinha A, Skrahina A, Solanki H, Solans BP, Soriano-Arandes A, Toktogonova A, van der Werf T, Velásquez GE, Williams B, Yim JJ, Savic R, Hesseling A.
Lancet Child Adolescent Health

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Heterologous Immunization with Improved HIV-1 Subtype C Vaccines Elicit Autologous Tier 2 Neutralizing Antibodies with Rapid Viral Replication Control After SHIV Challenge
Chege GK, Chapman RE, Keyser AT, Adams CH, Benn K, van Diepen MT, Douglass N, Lambson B, Hermanus T, Moore PL, Williamson AL.
Viruses

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Population shift in antibody immunity following the emergence of a SARS-CoV-2 variant of concern
Bhiman JN, Madzorera VS, Mkhize Q, Scheepers C, Hermanus T, Ayres F, Makhado Z, Moyo-Gwete T, Crowther C, Singh B, Fortuin M, Marinda E, Jooste S, Zuma K, Zungu N, Morris L, Puren A, Simbayi L, Moyo S, Moore PL.
Scientific Reports

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Evolving Epidemiology of Mpox in Africa in 2024
Ndembi N, Folayan MO, Komakech A, Mercy K, Tessema S, Mbala-Kingebeni P, Ngandu C, Ngongo N, Kaseya J, Abdool Karim SS.
NEJM

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Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development
Hesselman MC, Zeeb M, Rusert P, Pasin C, Mamrosh J, Kariuki S, Pichler I, Sickmann M, Kaufmann MM, Schmidt D, Friedrich N, Metzner KJ, Rindler A, Kuster H, Adams C, Thebus R, Huber M, Yerly S, Leuzinger K, Perreau M, Koller R, Dollenmaier G, Frigerio S, Westfall DH, Deng W, deCamp AC, Juraska M, Edupuganti S, Mgodi N, Murrell H, Garrett N, Wagh K, Mullins JI, Williamson C, Moore PL, Günthard HF, Kouyos RD, Trkola A
Cell Host Microbe

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Virologic Failure and Drug Resistance After Programmatic Switching to Dolutegravir-based First-line Antiretroviral Therapy in Malawi and Zambia
Skrivankova VW, Huwa J, Muula G, Chiwaya GD, Banda E, Buleya S, Chihota B, Chintedza J, Bolton C, Tweya H, Kalua T, Hossmann S, Kouyos R, Wandeler G, Egger M, Lessells RJ.
Clinical Infectious Diseases

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Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Hamilton F, Schurz H, Yates TA, Gilchrist JJ, Möller M, Naranbhai V, Ghazal P, Timpson NJ; Genes & Health Research Team; International Tuberculosis Host Genetics Consortium; Parks T, Pollara G.
Lancet Microbe

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Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial
Harris V, Holmes J, Gbinigie-Thompson O, Rahman NM, Richards DB, Hayward G, Dorward J, Lowe DM, Standing JF, Breuer J, Khoo S, Petrou S, Hood K, Ahmed H, Carson-Stevens A, Nguyen-Van-Tam JS, Patel MG, Saville BR, Francis N, Thomas NPB, Evans P, Dobson M, Png ME, Lown M, van Hecke O, Jani BD, Hart ND, Butler D, Cureton L, Patil M, Andersson M, Coates M, Bateman C, Davies JC, Raymundo-Wood I, Ustianowski A, Yu LM, Hobbs FDR, Little P, Butler CC; PANORAMIC Trial Collaborative Group.
Lancet Infectious Diseases

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Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
Marsden AA, Corcoran M, Hedestam GK, Garrett N, Karim SS, Moore PL, Kitchin D, Morris L, Scheepers C.
Immunogenetics

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Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance
Cohen P, Lambson BE, Mkhize NN, Moodley C, Yssel AEJ, Moyo-Gwete T, York T, Gwashu-Nyangiwe A, Ndabambi N, Thebus R, Juraska M, deCamp AC, Williamson BD, Magaret CA, Gilbert PB, Westfall D, Deng W, Mullins JI, Morris L, Williamson C, Moore PL.
Journal of Virology

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Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance
Cohen P, Lambson BE, Mkhize NN, Moodley C, Yssel AEJ, Moyo-Gwete T, York T, Gwashu-Nyangiwe A, Ndabambi N, Thebus R, Juraska M, deCamp AC, Williamson BD, Magaret CA, Gilbert PB, Westfall D, Deng W, Mullins JI, Morris L, Williamson C, Moore PL.
Journal of Virology

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