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Home / Scientific Publications

Scientific Publications

HIV disease progression in the first year after delivery among african women followed in the HPTN 046 clinical trial.
Watts DH, Brown ER, Maldonado Y, Herron C, Chipato T, Reddy L, Moodley D, Nakabiito C, Manji K, Fawzi W, George K, Richardson P, Zwerski S, Coovadia H, Fowler M.
Journal of Acquired Immune Deficiency Syndromes 2013; 64(3):299-306.

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Chest Radiograph Findings and Time to Culture Conversion in Patients with Multidrug-Resistant Tuberculosis and HIV in Tugela Ferry, South Africa.
Brust JCM, Berman AR, Zalta B, Haramati LB, Ning Y, Heo M, van der Merwe TL, Bamber S, Moll AP, Friedland GH, Shah NS, Gandhi NR.
PLoS ONE 2013; 8(9): e73975.

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No evidence for selection of HIV-1 with enhanced Gag-Protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.
Chopera DR, Mann JK, Mqimanzi P, Omarjee S, Kuang XT, Ndabambi N, Goodier S, Martin E, Naranbhai V, Abdool Karim SS, Abdool Karim Q, Brumme ZL, Ndung’u T, Williamson C, Brochman MA.
PLOS One 2013; 8(8):e71758.

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Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome.
Chang CC, Dorasamy AA, Gosnell BI, Elliott JH, Spelman T, Omarjee S, Naranbhai V, Coovadia Y, Ndung’u T, Moosa M-YS, Lewin SR, French MA.
AIDS 2013, 27(13):2089–99.

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Systematic review of clofazimine for the treatment of drug-resistant tuberculosis.
Gopal M, Padayatchi N, Metcalfe JZ, O’Donnell MR.
International Journal of Tuberculosis and Lung Disease 2013; 17(8):1001-1007.

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Anti-retrovirals for treatment and prevention - time for new paradigms in our response to the HIV/AIDS epidemic?
Abdool Karim Q, Bayer R.
Developing World Bioethics 2013; 13(2): 2-3.

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Balancing efficiency, equity and feasibility of HIV treatment in South Africa - development of programmatic guidance.
Baltussen R , Mikkelsen E, Tromp N, Hurtig A, Byskov J, Olsen T, Bærøe K, Hontelez JA, Singh J, Norheim OF.
Cost Effectiveness and Resource Allocation 2013;11(1):26.

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Addressing Ethical, Social, and Cultural Issues in Global Health Research.
Lavery JV, Green SK, Bandewar SVS, Bhan A, Daar A, Emerson CI, Masum H, Randazzo FM, Singh JA, Upshur REG, Singer PA.
PLoS Neglected Tropical Diseases 2013; 7(8):e2227.

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Why vulnerable young women at risk of HIV should be prioritized for access to preexposure prophylaxis.
Singh JA.
AIDS 2013; 27(12): 1998-99.

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Estimation of HIV Incidence in a Large, Community-Based, Randomized Clinical Trial: NIMH Project Accept (HIV Prevention Trials Network 043).
Laeyendecker O, Kulich M, Donnell D, Komárek A, Omelka M, Mullis CE, Szekeres G, Piwowar-Manning E, Fiamma A, Gray RH, Lutalo T, Morrison C, Salata RA, Chipato T, Celum C, Kahle EM, Taha TE, Kumwenda NI, Abdool Karim Q, Naranbhai V, Lingappa J, Sweat MD, Coates T, Eshleman SH. PLoS One 2013; 8(7): e68349. doi:10.1371/journal.pone.0068349

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Topical Microbicides—What’s New?
Abdool Karim Q, Cheryl Baxter C, Abdool Karim SS.
AIDS 2013; 63(Suppl. 2):S144–S149.

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Safety of coitally administered tenofovir 1% gel, a vaginal microbicide, in chronic hepatitis B virus carriers: Results from the CAPRISA 004 trial.
Baxter C, Yende-Zuma N, Tshabalala P, Abdool Karim Q, Abdool Karim SS.
Antiviral Research 2013; 99(3): 405-408.

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Adherence Support Approaches in Biomedical HIV Prevention Trials: Experiences, Insights and Future Directions from Four Multisite Prevention Trials.
Amico R, Mansoor LE, Corneli A, Torjesen K, van der Straten A.
AIDS Behav 2013; 17(6):2143-55.

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HIV pre-exposure prophylaxis in injecting drug users
Abdool Karim SS.
Lancet 2013; 381:2060-62.

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Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: A review of scientific, program, and policy advances for sub-Saharan Africa.
Chi BH, Stringer JSA, Moodley D.
Current HIV/AIDS Reports 2013; 10(2):124-133.

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Antiretroviral resource allocation for HIV prevention.
Singh JA.
AIDS 2013; 27(6):863-5.

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The Global HIV Epidemic: Current Status and Challenges.
Abdool Karim Q.
Current HIV/AIDS Reports 2013; 10(2):111-112.

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Health-care workers’ perspectives on workplace safety, infection control, and drug-resistant tuberculosis in a high-burden HIV setting
Zelnick JR, Gibbs A, Loveday M, Padayatchi N, O’Donnell MR.
Journal of Public Health Policy 2013; 34(3):388-402.

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Multiple Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies.
Moore PL, Sheward D, Nonyane M, Ranchobe N, Hermanus T, Gray ES, Abdool Karim SS, Williamson C, Morris L.
Journal of Virology 2013; 87(9):4882-94.

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Appropriateness of hydroxyethylcellulose gel as a placebo control in vaginal microbicide trials: A comparison of the two control arms of HPTN 035
Richardson BA, Kelly C, Ramjee G, Fleming T, Makanani B, Roberts S, Musara P, Mkandawire N, Moench T, Coletti A, Soto-Torres L, Abdool Karim SS for the HPTN 035 Study Team.
JAIDS 2013; 63(1):120-125.

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Challenges of Diagnosing Acute HIV-1 Subtype C Infection in African Women: Performance of a Clinical Algorithm and the Need for Point-of-Care Nucleic-Acid Based Testing
Mlisana K, Sobieszczyk M, Werner L, Feinstein A, van Loggerenberg F, Naicker N, Williamson C, Garrett N.
PLoS One 2013; 8(4): e62928.

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Recommendations for the follow-up of study participants with breakthrough HIV infections during HIV/AIDS biomedical prevention studies.
Etter P, Landovitz R, Sibeko S, Sobieszczyk ME, Riddler SA, Karg C, Tsibris A, Schouten J.
AIDS 2013; 27(7):1119–1128.

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Does participation in an HIV vaccine efficacy trial affect risk behaviour in South Africa?
Gray GE, Metch B, Churchyard G, Mlisana K, Nchabeleng M, Allen M, Moodie Z, Kublin J, Bekker L-G.
Vaccine 2013; 31(16):2085-96.

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Microbicide clinical trial adherence: insights for introduction.
Woodsong C, MacQueen K, Amico RK, Friedland B, Gafos M, Mansoor L, Tolley E, McCormack S.
Journal of the International AIDS Society 2013; 16:18505. doi.org/10.7448/IAS.16.1.18505

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Integrating patients’ perspectives into integrated TB/HIV healthcare.
Daftary A, Padayatchi N.
International Journal of Tuberculosis and Lung Diseases 2013; 17(4): 546-551.

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Diagnosis of drug-resistant TB and provision of second line TB treatment in India: some ethics considerations.
Singh JA, Bhan A, Upshur REG.
Indian Journal of Medical Ethics 2013; 10(2):110-114

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Community-based intervention is necessary for the control of HIV in North-Central Nigeria.
Ajoge HO, Yende-Zuma N, Jatau ED, Ibrahim S, Olonitola SO, Shittu OS.
International Journal of Infectious Diseases 2013;17(4):e234-9.

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Adverse events in an integrated home-based treatment program for MDR-TB and HIV in kwazulu-natal, South Africa.
Brust JCM , Shah NS, Van Der Merwe TL, Bamber S, Ning Y, Heo M, Moll AP, Loveday M, Lalloo UG, Friedland GH, Gandhi NR.
Journal of Acquired Immune Deficiency Syndromes 2013; 62(4):436-440.

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Co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection and AIDS.
Shey MS, Kongnyuy EJ, Alobwede SM, Wiysonge CS.
The Cochrane database of systematic reviews 2013; 3: CD005481. doi: 10.1002/14651858.CD005481.

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The changing epidemiology of HIV in 2013.
Beyrer C, Abdool Karim Q.
Current Opinion in HIV and AIDS 2013; 8(4):306-10.

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Women with Pregnancies Had Lower Adherence to 1% Tenofovir Vaginal Gel as HIV Preexposure Prophylaxis in CAPRISA 004, a Phase IIB Randomized-Controlled Trial.
Matthews LT, Sibeko S, Mansoor LE, Yende-Zuma N, Bangsberg DR, Abdool Karim Q.
PLoS One 2013; 8(3): e56400.

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Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection.
O’Donnell MR, Padayatchi N, Kvasnovsky C, Werner L, Master I, Horsburgh RC.
Emerging Infectious Diseases 2013; 19(3):416-24.

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Rapid, complex adaptation of transmitted HIV-1 full-length genomes in subtype C-infected individuals with differing disease progression.
Abrahams MR, Treurnicht FK, Ngandu NK, Goodier SA, Marais JC, Bredell H, Thebus R, de Assis Rosa D, Mlisana K, Seoighe C, Abdool Karim S, Gray CM, Williamson C.
AIDS 2013; 27(4):507-18.

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Feasibility, Performance, and Acceptability of the WisebagTM for Potential Monitoring of Daily Gel Applicator Use in Durban, South Africa.
van der Straten A, Montgomery E, Pillay D, Cheng H, Naidoo A, Cele Z, Naidoo K, Hartmann M, Piper J, Nair G.
AIDS Behav 2013; 17(2):640–648.

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The treatment journey of a patient with multidrug-resistant tuberculosis in South Africa: is it patient-centred?
Loveday M, Padayatchi N, Voce A, Brust J, Wallengren K.
International Journal of Tuberculosis and Lung Disease2013 Oct; 17(10 Suppl 1):56-9.

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Differential profiles and inhibitory effect on rotavirus vaccines of nonantibody components in breast milk from mothers in developing and developed countries.
Moon SS, Tate JE, Ray P, Dennehy PH, Archary D, Coutsoudis A, Bland R, Newell ML, Glass RI, Parashar U, Jiang B.
Pediatr Infect Dis J 2013,32(8):863-870.

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A critical analysis of ICU/HC beds in South Africa: 2008-2009.
Naidoo K, Singh J, Lalloo U.
South African Medical Journal 2013; 103(10):751-753.

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India's regulatory reforms on compensation for clinical trial injuries and deaths: urgent need for revisiting.
Singh JA.
Indian Jornal of Medical Ethics 2013,10(3):195-197.

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Impact of Maternal and Infant Antiretroviral Drug Regimens on Drug Resistance in HIV-infected Breastfeeding Infants.
Fogel JM , Mwatha A, Richardson P, Brown ER, Chipato T, Alexandre M, Moodley D, Elbireer A, Mirochnick M, George K, Mofenson LM, Zwerski S, Coovadia HM, Eshleman SH.
Pediatric Infectious Disease Journal 2013; 32(4):e164-169.

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Rifampicin mono-resistance in Mycobacterium tuberculosis in KwaZulu-Natal, South Africa: A significant phenomenon in a high prevalence TB-HIV region.
Coovadia YM, Mahomed S, Pillay M, Werner L, Mlisana K.
PLoS One 2013; 8(11):e77712.

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Identification of Broadly Neutralizing Antibody Epitopes in 1 the HIV-1 Envelope Glycoprotein using Evolutionary Models.
Lacerda M, Moore PL, Ngandu NK, Seaman M, Gray ES, Murrell B, Krishnamoorthy M, Nonyane M, Madiga M, Wibmer CK, Sheward D, Bailer RT, Gao H, Greene KM, Abdool Karim SS, Mascola JR, Korber BTM, Montefiori DC, Morris L, Williamson C, Seoighe C, the CAVD-NSDP Consortium.
Virology Journal 2013; 10(1):347.

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Development of Methods for Cross-Sectional HIV Incidence Estimation in a Large, Community Randomized Trial.
Laeyendecker O, Kulich M, Donnell D, Komárek A, Omelka M, Mullis CE, Szekeres G, Piwowar-Manning E, Fiamma A, Gray RH, Lutalo T, Morrison C, Salata RA, Chipato T, Celum C, Kahle EM, Taha TE, Kumwenda NI, Abdool Karim Q, Naranbhai V, Lingappa J, Sweat MD, Coates T, Eshleman SH.
PLoS One 2013; 8(11): e78818.

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Delineating antibody recognition in polyclonal sera from patterns of HIV-1-isolate neutralization.
Georgiev I, Doria-Rose NA, Zhou T, Do Kwon Y, Staupe RP, Moquin S, Chuang G-Y, Louder MK, Schmidt SD, Altae-Tran HR, Bailer RT, McKee K, Nason M, O’Dell S, Ofek G, Pancera M, Srivatsan S, Shapiro L, Connors M, Migueles SA, Morris L, Nishimura Y, Martin MA, Mascola JR, Kwong PD.
Science 2013; 340(6133):751-6.

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Comparison of Viral Env Proteins From Acute and Chronic Infections of Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences In Glycosylation and CCR5 Utilization and Suggests A New Strategy For Immunogen Design.
Ping L-H, Joseph SB, Anderson JA, Abrahams M-R, Salazar-Gonzalez JF, Kincer LP, Treurnicht FK, Arney L, Ojeda S, Zhang M, Keys J, Potter EL, Chu H, Moore P, Salazar-Gonzalez M, Iyer S, Jabara C, Kirchherr J, Mapanje C, Ngandu N, Seoighe C, Hoffman I, Gao F, Tang Y, Labranche C, Lee B, Saville A, Vermeulen M, Fiscus S, Morris L, Abdool Karim S, Haynes BF, Shaw GM, Korber BT, Hahn BH, Cohen MS, Montefiori D, Williamson C, Swanstrom R, for the CAPRISA Acute Infection Study and the Center for HIV-AIDS Vaccine Immunology Consortium.
Journal of Virology 2013; 87(13):7218-33.

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Accelerating the Development of a Safe and Effective HIV Vaccine: HIV Vaccine Case Study for the Decade of Vaccines.
Koff WC, Russell ND, Walport M, Feinberg MF, Shiver JW, Abdool Karim SS, Walker BD, McGlynn MG, Nweneka CV, Nabel GJ.
Vaccine 2013; 31(Suppl 2):B204-8. doi: 10.1016/j.vaccine.2012.10.115.

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Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253.
Swindells S, Komarow L , Srikanth T, Cain KP, MacGregor R, Achkar J, Gupta A, Santos V, Asmelash A, Omozoarhe AE, Gengiah S, Lalloo U, Allen R, Shibosk C, Andersen J, Qasba S, Katzenstein DK.
International Journal of Tuberculosis and Lung Disease 2013; 17(4):532-539.

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Safety of Tenofovir Gel, a Vaginal Microbicide, in South African Women: Results of the CAPRISA 004 Trial.
Sokal D, Abdool Karim Q, Sibeko S, Yende-Zuma N, Mansoor LE, Baxter C, Grobler A, Frohlich J, Kharsany A, Mlisana K, Maarshalk S, Abdool Karim SSA.
Antiviral Therapy 2013; 18(3):301-310.

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When to start antiretroviral therapy during tuberculosis treatment?
Naidoo K, Baxter C, Abdool Karim SS.
Current Opinion in Infectious Diseases 2013; 26(1):3542.

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Changes in Natural Killer Cell Activation and Function during Primary HIV-1 Infection.
Naranbhai V, Altfeld M, Abdool Karim SS, Ndung’u T, Abdool Karim Q,Carr WH.
PLoS ONE 2013 8(1): e53251.

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Neither microbial translocation nor TLR responsiveness are likely explanations for pre-existing immune activation in women who subsequently acquired HIV in CAPRISA004.
Naranbhai V, Samsunder N, Sandler NG, Roque A, Abdool Karim Q, Ndung'u T, Carr WH, Altfeld M, Douek DC, Abdool Karim SS; and The CAPRISA004 Trial Team.
JAIDS 2013; 63(3):294–298.

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Microbicides for the prevention of sexually transmitted HIV infection.
Abdool Karim Q, Baxter C.
Expert Review of Anti- Infective Therapy 2013; 11(1):13-23.

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HIV/AIDS and admission to intensive care units: A comparison of India, Brazil and South Africa.
Naidoo K, Singh JA, Lalloo U.
S Afr J HIV Medicine 2013;14(1):15-16.

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Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.
Liu MKP, Hawkins N, Ritchie AJ, Ganusov VV, Whale V, Brackenridge S, Li H, Pavlicek JW, Cai F, Rose-Abrahams M, Treurnicht F, Hraber P, Riou C, Gray C, Ferrari G, Tanner R, Ping LH, Anderson JA, Swanstrom R, Cohen M, Abdool Karim SS, Haynes B, Borrow P, Perelson AS, Shaw GM, Hahn BH, Williamson C, Korber BT, Gao F, Self S, McMichael A, Goonetilleke N.
Journal of Clinical Investigation 2013; 123(1): 380-393.

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Viral Escape from HIV-1 Neutralizing 1 Antibodies 2 Drives Increased Plasma Neutralization Breadth through Sequential recognition of Multiple Epitopes and Immunotypes.
Wibmer CK, Bhiman JN, Gray ES, Tumba N, Abdool Karim SS, Williamson C, Morris L, Moore PL.
PLoS Pathog 2013; 9(10): e1003738. d

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Bigotry and Oppressive Laws in Africa Drive HIV in Men Who Have Sex with Men.
Singh JA.
PLoS Medicine 2013; 10(6): e1001471.

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