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Examining the immunological and metabolic effects of maternal ARVs

Dr Sinaye Ngcapu, CAPRISA scientist, was awarded an R01 research grant earlier this year by the NIH-SAMRC Joint Call.

The 5 year study will determine whether specific vaginal anaerobic microbes and associated inflammation can influence preterm deliveries or the  acquisition of HIV infections.

The study will also examine the immunological and metabolic effects of maternal ARV use during pregnancy on infant health without HIV exposure. This will inform the risk-benefit analysis of maternal PrEP explained Ngcapu.

“This study has the potential to lead to more refined interventions to mitigate risks of adverse birth outcomes, HIV acquisition and neonatal morbidity,” he said.