CAPRISA - Centre for the AIDS Programme of Research in South Africa.
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Influence of Interleukin-10 promoter polymorphisms |
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 Results from the CAPRISA 002 Acute Infection study, investigating the influence of Interleukin-10 promoter polymorphisms on susceptibility and primary HIV-1 pathogenesis was published in the Journal of Infectious Diseases earlier this year. The Interleukin-10 (IL-10) proximal promoter region consists of 2 known bi-allelic polymorphisms, which are related to levels of IL-10 production. Polymorphisms resulting in decreased production have been shown to increase likelihood of HIV-1 acquisition and accelerate CD4 decline. This has led to the suggestion that IL-10 may protect against disease progression. However, more recent animal models with lymphocytic choriomeningitis virus have suggested that removal of IL-10 enhanced T cell immune responses, development of antiviral memory and viral clearance.
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Bill Gates visits UKZN on World AIDS Day |
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(a) Bill Gates (second from bottom right) discusses the PrEP agenda with numerous distinguished scientists including CAPRISA Director Prof SS Abdool Karim (second from bottom right). (b) Bill Gates discussing research with CAPRISA Fellow Dr Vivek Naranbhai n HPP laboratory. |
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Last Updated ( Friday, 15 January 2010 07:19 )
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Microbicide Trials Network, Cape Town meeting |
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Attending the MTN meeting were (L-R): Ms Anushka Naidoo, Dr Leila Mansoor, Dr Ayesha Kharsany, Ms Londiwe Luthuli, Phindile Tshabalala, Ms Kalendri Naidoo, Ms Tanuja Gengiah and Dr Gonasagrie Nair. |
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Last Updated ( Friday, 15 January 2010 08:01 )
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Prestigious TWAS Prize in Medical Sciences |
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Prof Salim Abdool Karim (Right) receiving the TWAS award from rof Jacob Palis, President of TWAS Professor Salim Abdool Karim, was recently awarded the prestigious TWAS Prize in Medical Sciences. Formerly known as the Third World Academy of Sciences, TWAS is an autonomous international organization of internationally renowned scientists who are elected by their peers. TWAS Prizes, which include a cheque for US$ 15,000, are awarded to individual scientists in developing countries in recognition of outstanding contributions to knowledge. |
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CAPRISA 004 tenofovir gel trial has been completed |
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  Congratulations to the CAPRISA 004 tenofovir gel trial teams from eThekwini (top)) and Vulindlela (above) for their hard work on the APRISA 004 tenofovir gel trial which has Officially closed on 10 December 2009. |
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Last Updated ( Friday, 15 January 2010 08:01 )
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Results from the CAPRISA 002 Acute Infection Study |
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Results from the CAPRISA 002 Acute Infection Study, investigating the role of neutralizing antibodies in neutralization escape of subtype C virus, was published recently in PLoS Pathogens. In most HIV-1 infected individuals neutralizing antibodies that target the Env region of the virus develop and reach detectable levels in the first few months of infection and subsequently block viral entry. It is presumed that the pressure exerted by autologous neutralizing antibodies may account for much of the variation that occurs in Env during early infection. In both HIV-1 subtype B and SIV, neutralization escape has been documented with contemporaneous viruses showing less sensitivity to autologous neutralization than the earlier virus. In subtype C infection however, the autologous neutralizing antibody response appears to differ somewhat to the subtype B virus and is less well characterized.
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iDART goes live at CAPRISA Pharmacies |
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The CAPRISA Vulindlela and eThekwini Pharmacies transitioned their manual dispensing processes for all projects in the CAPRISA AIDS Treatment Program to the iDART computerized system mid September 2009. The Intelligent Dispensing of ART (iDART) software is used by the pharmacist to manage ARV stocks, print reports and manage collection of drugs by patients. |
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