Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies.
Broadly cross-neutralizing (BCN) antibodies are likely to be critical for an effective HIV vaccine. However the ontogeny of such antibodies, and their relationship with autologous viral evolution is unclear. Here we characterized viral evolution in CAP256, a subtype C infected individual who developed potent BCN antibodies targeting R166 and K169 in the V2 region.
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